Abstract: Objective To evaluate the efficacy of cyst puncture aspiration in treating abdominal echinococcosis.Methods A retrospective analysis was performed in 40 cases of abdominal echinococcosis with formation of isolated single cyst in close adhesion with the abdominal wall, for which cyst puncture aspiration was carried out under ultrasound guidance.Results No death occurred in these patients and only 15 developed mild fever. The days for antibiotic use, jaundice resolution, bile secretion, time of extubation and hospital stay were 2.88±0.65, 3.50±0.71, 4.25±0.96, 5.38±0.98 and 9.35±1.08 days, respectively. Ultrasound examination in the follow-up showed no relapse in these patients, with the time of the residue adhesive cyst closure and calcification of 4.50±1.13 and 13.90±2.38 months, respectively.Conclusion Cyst puncture aspiration under ultrasound guidance produces good therapeutic effects on abdominal echinococcosis with isolated single cyst closely adhering to the abdominal wall.