Abstract: Objective To explore the techniques of hand-assisted laparoscopic partial hepatectomy and its clinical value in the treatment of primary liver cancer. Methods Six patients with primary liver cancers in the segmentsⅡ, Ⅲ, Ⅴ, Ⅵ and on the edge of the liver received laparoscopic partial hepatectomy assisted by special instruments such as hand-assisted devices, harmonic scalpel, and Endo-GIA. Results All of the 6 operations were completed successfully, in which resections of both Ⅱ and Ⅲ segments, Ⅵ segment, and non-regular segment were performed. The operative time was 54 to 130 min and postoperative hospital stay 6-9 days, with intraoperative blood loss of 150-700 ml. No conversion to laparotomy was needed, nor did any complications occur. Postoperative follow-up lasted for 6 to 15 months, during which relapse occurred in 2 cases 3 months and 4 months after the operations respectively, while no recurrence has been found in the other 4 patients. Conclusion Hand-assisted laparoscopic partial hepatectomy is safe and feasible for primary liver cancer in clinically selected patients.