Human complement components C4 and Bf polymorphisms and their complotypes in Guangdong Chinese Han population

Abstract

Abstract: Objective To investigate the genetic polymorphism of human complement components C₄ and Bf and their complotype frequencies in Chinese Han population in Guangdong Province of China. Methods The genetic polymorphisms and complotypes of Bf, C₄A and C₄B, which were 3 components of HLA-Ⅲ, were analyzed in 144 chromosomes of subjects from healthy Han families in Guangdong Province. Results Thirteen variable complotypes were identified, led by the complotypes of S₃₂, S₃₁, S₄₂ and F₄₂ among which strong linkage disequilibria were observed. The most common phenotypes were BFS, C₄A₃, C₄A₄, C₄B₂ and C₄B₁. Conclusion The genetic polymorphism of C₄ and Bf and their complotypes have their own genetic predisposition in Chinese Han population in Guangdong Province.

CLC Number:

R392

YANG Li-ping¹, WEN Xiu-qing², GUAN Yan-bing³, XU Juan⁴, JIANG Xiao-dan⁵, ZHAO Xiu-zhu⁵. Human complement components C₄ and Bf polymorphisms and their complotypes in Guangdong Chinese Han population[J]. Journal of Southern Medical University, 2004, 24(09): 1026-1028.

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Human complement components C₄ and Bf polymorphisms and their complotypes in Guangdong Chinese Han population

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