Abstract: Objective To study the value of color echocardiography in diagnosis of neonatal cyanotic congenital heart disease (NCHD). Method A total of 149 cyanotic neonates were examined by color echocardiography, of whom 25 were diagrosed having NCHD and analyzed for classification. Results Such complex deformities as transposition of the major arteries, tetralogy of Fallot, single ventricle, persistent truncus arteriosus were found in these 25 cases of NCHD, of which major artery transposition was the most common defects, followed by tetralogy of Fallot and then by single ventricle. Conclusion Color echocardiography can be used routinely in diagnosis of congenital heart disease of cyanotic neonates.