HLA-Cw alleles polymorphism and haplotypes in Guangdong Han population

Abstract

Abstract: Objective To analyze the polymorphism and haplotypes of HLA-Cw and detect HLA-A, B, Cw and DRB1 allele frequencies in Guangdong Han population. Method An auto semi-quantitative PCR with reverse sequence-specific oligonucleo- tide was adopted to explore the HLA-A, B, Cw and DRB1 genotypes of 185 bone marrow donors. Result Eleven HLA-Cw alleles were obtained in which Cw^*03 (0.2580), 07 (0.1887), 01 (0.1732), and 08 (0.1071) had much higher allele frequencies. A total of 7 HLA-Cw-A, 20 HLA-Cw-B and 10 HLA-Cw-DRB1 haplotypes were found. Conclusion HLA-Cw alleles have richer polymorphisms and their linkage disequilibrium with HLA-A, B, DRB1 exhibits geographic genetic characteristics.

CLC Number:

R392.13

MA Hong-jing¹, XIAO Lu-lu², Yin Xiao-lin¹, GUO Kun-yuan¹, Ye Xin². HLA-Cw alleles polymorphism and haplotypes in Guangdong Han population[J]. Journal of Southern Medical University, 2004, 24(08): 900-903.

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