HepatosplenicγδT-cell lymphoma:a clinicopathological study

Abstract

Abstract: Objective To explore the clinicopathologic features and immunophenotype of hepatosplenicγδT-cell lymphoma.Methods A case of hepatosplenic γδT-cell lymphoma was stud ied with conventional histopathological and immunohisto-chemical staining in com bination of literature review.Results Diffuse hepatic and splenic enlargement w as found in this case. Microscopically, the liver and spleen showed marked sinu soidal infiltration. The cells of hepatosplenic T-cell lymphoma were homogeneou s, medium in size with pale cytoplasm, and the nuclear chromatin was loosely con densed with small inconspicu-ous nucleoli. The neoplastic cells were positive fo r CD45RO, CD3 and TIA-1, but negative for CD57, CD20 and CD79a.Conclusion Hepa tosplenic γδT-cell lymphoma is a rare form of peripheral T-cell lymphoma and h as usually poor prognosis, which should be differentiated from other lymphomas or leukemia.

CLC Number:

R733

GENG Jian, ZHU Mei-gang, DING Yan-qing, HAN Hui-xia. HepatosplenicγδT-cell lymphoma:a clinicopathological study[J]. Journal of Southern Medical University, 2004, 24(01): 88-90.

References

[1] Cooke CB,Krenacs L,Stetler-Stevenson M,et al. Hepatosplenic T-cell lymphoma:a distinct clinicopathologic entity of cytotoxic gamma delta T-cell origin[J]. Blood,1996,88(11):4265-74.
[2] de Wolf-Peet. ers C,Achten R Gammadelta T-cell lymphomas:a homogeneous entity[J] ? Histopathology,2000,36(4):294-305.
[3] Kadin ME,Kamoun M,Lamberg J. Erythrophagocytic T gamma lymphoma:a clinicopathologic entity resembling malignant histiocytosis[J].N Engl J Med,1981,12,304(11):648-53.
[4] Gaulard P,Zafrani ES,Mavier P,et al. Peripheral T-cell lymphoma presenting as predominant liver disease:a report of three cases[J].Hepatology,1986,6(5):864-8.
[5] Jaffe ES,Harris NL,Diebold J,et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. A progress report[J]. Am J Clin Pathol,1999,111(1Suppl 1):S8-12.
[6] SalhanyKE,FeldmanM,KahnMJ,et al. Hepatosplenicgammadelta T-cell lymphoma:ultrastructural,immunophenotypic,and functional evidence for cytotoxic T lymphocyte differentiation[J].Hum Pathol,1997,28(6):674-85.
[7] 皋岚湘,丁华野,严庆汉.肝脾γST细胞淋巴瘤[J].中华病理学杂志(ChinJPatho1),2002,31(4):348-51.
[8] 陈琪,平宝红,周淑芸.原发性结外淋巴瘤误诊分析[J].第一军医大学学报(JFirstMilMedUniv/DiYi JunYiDaXueXueBao),2001,21(5):350.
[9] Wong KF,Chan JK,Matutes E,et al. Hepatosplenic gamma delta T-cell lymphoma. A distinctive aggressive lymphoma type[J]. Am J Surg Pathol,1995,19(6):718-26.
[10] 徐兵,胡成,缪旭东,等.106例成人急性白血病流式细胞术免疫分型分析[J].第一军医大学学报,2003,23(10):1043-6.Xu B,Hu C,Miao XD,et al. Immunophenotyping of 106 adult patients with acute leukemia by flow cytometry[J]. J First Mil Med Univ/Di Yi Jun Yi Da Xue Xue Bao,2003,23(10):1043-6.
[11] Weidmann E. Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990[J]. Leukemia,2000,14(6):991-7.

[1]	. [J]. Journal of Southern Medical University, 2006, 26(12): 1831-1831.
[2]	FAN Zhi-ping, YANG Kai, LIU Qi-fa, SUN Jing, XU Dan, ZHANG Yu, WEI Yong-qiang, YE Chang-xiong, JIANG Qian-li, MENG Fan-yi Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. A comparative study of unrelated donor bone marrow transplantation and peripheral blood stem cell transplantation for their therapeutic effects on leukemia [J]. Journal of Southern Medical University, 2006, 26(10): 1494-.
[3]	FU Yun-bi1, LI Gui-ping2, MENG Fan-Yi1 1Department of Hematology, 2Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Labeling of CDTPA-dianhydride-coupled CD45 monoclonal antibody with yttrium-90 [J]. Journal of Southern Medical University, 2006, 26(08): 1230-1232.
[4]	ZHOU Jue-yu1,MA Wen-li1,FEI Jia2,DING Da-peng1,SHI Rong1,JIANG Li1,ZHENG Wen-ling3 1Institute of Genetic Engineering,Southern Medical University,Guangzhou 510515,China;2Department of Biochemistry and Molecular Biology,Medical College of Jinan University,Guangzhou 510632,China;3South China Genomics Research Center,Guangzhou 510800,China. Effects of microRNA miR-181a on gene expression profiles of K562 cells [J]. Journal of Southern Medical University, 2006, 26(05): 606-609.
[5]	. [J]. Journal of Southern Medical University, 2006, 26(05): 638-639.
[6]	SHEN Li-jia, FANG Wei-yi, XIE Si-ming, HE Ying, JIANG Hui-yong, ZHAO Tong Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Expression and cloning of mCD99L2 gene from mouse B lymphoma cell line A20 and construction of its eukaryotic expression vector [J]. Journal of Southern Medical University, 2006, 26(02): 144-149.
[7]	WEI Li, LUO Rong-cheng, ZHANG Jun-yi, YAN Xiao, FANG Yong-xin, FEI Li-hua Center of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Biological response of B-cell lymphoma cells in vitro to 131I-rituximab [J]. Journal of Southern Medical University, 2006, 26(02): 211-213.
[8]	CHEN Wei, LUO Rong-cheng, FAN Wei-wen, MA Shu-dong Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Clinical value of combined detection of LDH, TPS, CEA and β2-MG in patients with non-Hodgkin’s lymphoma [J]. Journal of Southern Medical University, 2006, 26(02): 227-.
[9]	LI Ning, QIAN Xin-hua, Wang Zhi-yuan Department of Pediatrics, Nanfang Hospital, Department of Teaching Affairs, Southern Medical University, Guangzhou 510515, China. Specific inhibition of gene expression of lung resistance-related protein by short interfering RNA [J]. Journal of Southern Medical University, 2006, 26(01): 1-5.
[10]	SHEN Ce¹, LIU Hao¹, ZUO Qiang², ZHANG Jun-yi², YANG Jin-xing². Effects of short-term chemotherapy on the compliance of rabbit abdominal aorta [J]. Journal of Southern Medical University, 2005, 25(11): 1443-1445.
[11]	XU Bing, LI Lin, TANG Jia-hong, ZHOU Shu-yun. Detection of FLT3 gene and FLT3/ITD mutation by polymerase chain reaction-single-strand conformation polymorphismin in patients with acute lymphoblastic leukemia [J]. Journal of Southern Medical University, 2005, 25(10): 1207-1210.
[12]	LIU Fang-ying¹, CHEN Dan², SHANG Jian-biao³, WU Xiao-mei⁴, ZHANG Xue-lin¹. Clinical and imaging diagnosis of primary hepatic lymphoma [J]. Journal of Southern Medical University, 2005, 25(10): 1290-1292.
[13]	LI Wen-li, HAI Chun-xu, YANG Chen, LI Bo, LIU Rui, ZHANG Xiao-di. Apoptosis of pulmonary epithelial cells and endothelial cells in mice exposed to phosgene [J]. Journal of Southern Medical University, 2005, 25(08): 983-985,990.
[14]	LIU Qi-fa, FAN Zhi-ping, SUN Jing, ZHANG Yu, LIU Xiao-li, XU Dan, XU Bing, FENG Ru, MENG Fan-yi, ZHOU Shu-yun. Therapeutic efficacy of hematopoietic stem cell transplantation in patients with chronic myelogenous leukemia [J]. Journal of Southern Medical University, 2004, 24(11): 1227-1229,1241.
[15]	. Angioimmunoblastic T-cell lymphoma with distinct follicular hyperplasia:report of one case [J]. Journal of Southern Medical University, 2004, 24(11): 1330-1332.