Mathematical model of epidermal growth factor receptor-mediated lipid phosph atidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1activity

Journal of Southern Medical University ›› 2004, Vol. 24 ›› Issue (01): 18-20,23.

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Mathematical model of epidermal growth factor receptor-mediated lipid phosph atidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1activity

SU Yong-chun¹, DENG Fan², LU Di², BAI Xiao-chun², TAN Xiao-dan¹, DONG Ai-rong¹, LUO Shen-qiu², DENG Qin-kai¹

1. 第一军医大学, 医学物理学教研室, 广东, 广州, 510515;
2. 第一军医大学, 细胞生物学教研室, 广东, 广州, 510515

Online:2004-01-20 Published:2004-01-20

Abstract

Abstract: Objective To investigate the dynamic characteristics of lipid phosphatidylinositol (4,5)-bisphosphate (PIP₂) in plasma membrane hydrolyzed by phospholipase C-gamma1 in epidermal grow th factor receptor(EGFR)-mediated signal path-way.Methods A mathematical model based on the law of mass action was established with differential equations to s imulate metabolizable pathway of PIP₂.Results Differential equations of the key product concentration during hyd rolysis of PIP₂ were formulated, and the effects of the parameters on these hydrolyzed pro ducts analyzed.Conclusion This mathematical model provides foundation for furt her investigation of the dynamic changes of biological characteristics and the r elations between the key product concentrations in PIP₂ hydrolysis.

CLC Number:

SU Yong-chun¹, DENG Fan², LU Di², BAI Xiao-chun², TAN Xiao-dan¹, DONG Ai-rong¹, LUO Shen-qiu², DENG Qin-kai¹. Mathematical model of epidermal growth factor receptor-mediated lipid phosph atidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1activity[J]. Journal of Southern Medical University, 2004, 24(01): 18-20,23.

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Mathematical model of epidermal growth factor receptor-mediated lipid phosph atidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1activity

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