南方医科大学学报

南方医科大学学报 ›› 2017, Vol. 37 ›› Issue (03): 415-.

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超敏反应蛋白、纤维蛋白原和D-二聚体在结缔组织病相关间质性肺炎中的临床意义

袁思捷，谢海庭，李忠丽   

  • 出版日期:2017-03-20 发布日期:2017-03-20

Clinical significance of hypersensitive C-reactive protein, fribrinogen and D-dimmer in connective tissue disease-related interstitial lung disease

  • Online:2017-03-20 Published:2017-03-20

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摘要： 目的观察超敏C反应蛋白、纤维蛋白原和D-二聚体在结缔组织病相关间质性肺炎（CTD-ILD）和非结缔组织病相关间质 性肺炎（NCTD-ILD）患者血浆中的浓度高低，探究其相关性及临床意义。方法选取2010年1月~2016年4月南方医科大学珠 江医院收治的间质性肺炎患者69例，分为CTD-ILD组（30例）和NCTD-ILD组（39例）作为研究对象，同期纳入25例健康人作为 对照组，行超敏C反应蛋白、纤维蛋白原和D-二聚体检测。结果CTD-ILD组和NCTD-ILD组的超敏C反应蛋白、纤维蛋白原 和D-二聚体浓度均高于对照组（P<0.05）；CTD-ILD组的超敏C反应蛋白浓度高于NCTD-ILD组（P<0.05），但两组间的纤维蛋 白原和D-二聚体浓度无差异；超敏C反应蛋白浓度分别与D-二聚体浓度、纤维蛋白原浓度呈正相关（r分别为0.539、0.534，P< 0.01）。结论超敏C反应蛋白、纤维蛋白原和D-二聚体对间质性肺炎的临床诊断有重要意义，超敏C反应蛋白的明显升高与合 并结缔组织病相关。

Abstract: Objective To investigate the clinical significance of plasma levels of hypersensitive C-reactive protein (hs-CRP), fibriogen and D-dimmer (D-DI) in patients with connective tissue disease (CTD)-related interstitial lung disease (CTD-ILD). Methods Sixty-nine patients with interstitial lung disease admitted in Zhujiang Hospital between January, 2010 and April, 2016, including 29 with CTD-ILD and 40 with non-CTD-ILD were analyzed for plasma levels of hs-CRP, fibriogen and D-DI, with 25 healthy subjects as the control group. Results The plasma level of hs-CRP, fibriogen and D-DI in patients with CTD-ILD and non-CTD-ILD were all significantly higher than those in the control group. The patients with CTD-ILD had a significantly higher hs-CRP level than those with non-CTD-ILD, but the levels of fibriogen and D-DI were comparable between the two groups. Correlation analysis indicated that Hs-CRP level was positively correlated with the levels of D-DI (r=0.539, P< 0.01) and fibrinogen (r=0.534, P<0.01). Conclusion Hs-CRP, fibriogen and D-DI levels show an important value in clinical diagnosis of CTD, and an obvious elevation of hs-CRP is correlated with the CTD.