南方医科大学学报

南方医科大学学报 ›› 2016, Vol. 36 ›› Issue (10): 1406-.

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血清可溶性CD163在心房颤动患者中的水平及临床意义

钟世茂，覃羽华，黎作茶，韦叶生   

  • 出版日期:2016-10-20 发布日期:2016-10-20

Clinical value of detecting serum soluble CD163 level in patients with atrial fibrillation

  • Online:2016-10-20 Published:2016-10-20

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摘要： 目的探讨心房颤动（AF）和血清中可溶性CD163的关系。方法选取本院就诊的336例心脏瓣膜病患者，分为AF组和窦 性心律组。比较两组的基本资料，采用Logistic回归分析分析与AF相关的危险因素。结果两组患者实验室检测比较结果显 示，总胆固醇（TC）、高密度脂蛋白（HDL-C）和低密度脂蛋（LDL-C）、肿瘤坏死因子（TNF）、白介素-6（IL-6）以及高敏C反应蛋白 （hs-CRP）以及左房内径（LAD）具有统计学差异（P<0.05）。血清可溶性CD163在AF组明显高于窦性心律组，差异存在统计学 差异（P<0.05）。在AF 患者中，血清可溶性CD163 与TNF（r=0.244，P=0.002）、IL-6（r=0.186，P=0.016）、hs-CRP（r=-0.183，P= 0.018）以及LAD（r=0.194，P=0.012）正相关。Logistic回归分析结果显示，LAD、IL-6、TNF、hs-CRP和血清可溶性CD163与AF 密切相关。ROC曲线分析结果显示，血清可溶性CD163 对AF患者评估价值的曲线下面积为0.861（CI95%：0.820-0.901；P< 0.01），敏感度为80.8，特异度为76.9%。结论血清可溶性CD163可能是AF的一个风险因素，升高的可溶性CD163可以作为判 断AF患者炎症反应的理想指标。

Abstract: Objective To investigate the relationship between atrial fibrillation (AF) and serum soluble CD163. Methods A total of 336 patients with heart valve disease were included in this study, including 167 with AF and 169 with sinus rhythm. The clinical data were compared between the two grops, and Logistic regression analysis was used to identify the risk factors associated with AF. Results The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), tumor necrosis factor (TNF), interleukin-6 (IL - 6), high-sensitivity C-reactive protein (hs-CRP) and left atrial diameter (LAD) all differed significantly between the two groups (P<0.05). Serum soluble CD163 levels in AF patients were significantly higher than those in patients with sinus rhythm (P<0.05). Serum soluble CD163 was positively correlated with TNF (r=0.244, P=0.244), IL-6 (r=0.186, P=0.186), hs-CRP (r=0.183, P=0.183) and LAD (r=0.194, P=0.194) in patients with AF. Logistic regression analysis showed that LAD, IL-6, TNF, hs-CRP and CD163 were all associated with AF. ROC curve analysis showed that the area under curve of serum soluble CD163 was 0.861 in patients with AF (CI 95%: 0.820-0.901, P<0.01) with a sensitivity and a specificity of 80.8 and 76.9%, respectively. Conclusion Serum soluble CD163 level may be a risk factor for AF, and an increased soluble CD163 level may indicate active inflammation in AF patients.