南方医科大学学报

南方医科大学学报 ›› 2016, Vol. 36 ›› Issue (08): 1134-.

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肝细胞癌患者外周血循环肿瘤细胞阳性提示预后不良

郭柏棠，刘新城，黄毓，区活辉，李湘竑，杨定华   

  • 出版日期:2016-08-20 发布日期:2016-08-20

Positive circulating tumor cells in the peripheral blood may indicate a poor prognosis in patients with hepatocellular carcinoma

  • Online:2016-08-20 Published:2016-08-20

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摘要： 目的评价外周血循环肿瘤细胞（CTCs）检测在肝细胞癌临床诊治中的应用价值。方法随机选取2013年7月~2015年1 月期间南方医院肝胆外科收治的肝细胞癌患者296例为肝细胞癌组，并同时收集39例非肿瘤或肝脏良性肿瘤患者为对照组，采 用广州益善生物技术股份有限公司开发的CanPatrolTM CTCs检测技术检测肝细胞癌组及对照组患者外周血中CTCs的分布情 况，并分析外周血CTCs阳性与肝细胞癌患者临床病理参数之间的关系，以及CTCs与肝细胞癌患者术后无瘤生存时间的关 系。结果在对照组患者外周血中未检测到CTCs，在肝细胞癌组中，191例患者外周血中检测到CTCs，阳性率为64.5%，显著高 于对照组（P<0.05）；肝细胞癌患者外周血中CTCs阳性与患者血清甲胎蛋白水平、肿瘤数量、TNM分期、BCLC分期、门静脉癌栓 及转移等显著相关（P<0.05）；在127例接受根治性手术治疗的肝细胞癌患者中，CTCs阳性的肝细胞癌患者术后无瘤生存时间 显著缩短（P<0.05）。结论肝细胞癌患者外周血CTCs阳性提示预后不良，CTCs可以成为监测肝细胞癌患者预后一个较好的 辅助指标。

Abstract: Objective To assess the value of detecting peripheral blood circulating tumor cells (CTCs) in the diagnosis and treatment of hepatocellular carcinoma (HCC). Methods A total of 296 patients diagnosed with HCC admitted in our department from July 2013 to January 2015 were analyzed, with 39 patients with benign liver disease serving as the control group. The distribution of CTCs in the peripheral blood of HCC patients were detected by CanPatrolTM CTCs, and its relationship with the clinical features and prognosis of the patients were analyzed. Results CTCs were detected in 64.5% (191/ 296) of the HCC patients but in none of the control group (P<0.05). Positive CTCs in peripheral blood of HCC patients were significantly correlated with serum AFP level, tumor number, TNM stage, BCLC stage, portal vein tumor thrombus and metastasis (P<0.05). In 127 HCC patients receiving radical surgery, the patients positive for CTCs showed significantly shorter relapse-free survival time (P<0.05). Conclusion Positive CTCs in the peripheral blood may indicate a poor prognosis in HCC patients. CTCs may serve as a indicator for monitoring the prognosis of HCC.