南方医科大学学报

南方医科大学学报 ›› 2016, Vol. 36 ›› Issue (06): 875-.

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红细胞分布宽度联合脂蛋白相关磷脂酶A2检测可提高冠心病患者的冠状动脉狭窄程度诊断的准确性

刘季晨，郭凯，卢浩，李梦豪，赖文岩，郭志刚   

  • 出版日期:2016-06-20 发布日期:2016-06-20

Red blood cell distribution width combined with lipoprotein-associated phospholipase A2 detection for improving diagnostic accuracy of coronary artery stenosis in patients with coronary artery disease

  • Online:2016-06-20 Published:2016-06-20

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摘要： 目的探讨红细胞分布宽度（RDW），脂蛋白相关磷脂酶A2（LP-PLA2）与冠心病（CAD）患者的冠状动脉狭窄程度的关系 以及分析其对CAD患者的冠状动脉狭窄程度的诊断的准确性。方法选取2013年6月~2014年6月，在我院就诊的患者共224 例，其中non-CAD119 例，CAD 组105 例，收集其年龄、性别、BMI 等临床基本资料，抽取其静脉，检测其白细胞（WBC）、 RDW-CV、LP-PLA2等指标。根据冠脉造影结果，对CAD组患者计算Gensini积分，使用独立样本的t检验、卡方检验、pearson 相关系数分析、多重线性回归分析等统计学方法，对数据进行处理。结果CAD组的RDW-CV（P=0.009）和LP-PLA2（P=0.004） 明显高于non-CAD组；高分组RDW-CV（P=0.001）和LP-PLA2（P<0.001）明显高于低分组；RDW-CV、LP-PLA2与Gensini有明 显相关性；AUG（RDW-CV+LP-PLA2）=0.931。结论联合RDW-CV与LP-PLA2可提高CAD患者的冠状动脉狭窄程度诊断的 准确性。

Abstract: Objective To study the association of red blood cell distribution width (RDW) and lipoprotein-associated phospholipase A2 (LP-PLA2) with the degree of coronary artery stenosis in patients with coronary artery disease (CAD) and the value of RDW combined with LP-PLA2 detection in accurate evaluation of coronary artery stenosis. Methods A total of 224 patients including 119 non-CAD cases and 105 CAD cases admitted in our hospital between June, 2013 and June, 2014 were enrolled in this study. The patients’ baseline clinical data were collected and venous blood samples were obtained for detecting WBC, RDW-CV and LP-PLA2. The Gensini score of the CAD patients was calculated based on coronary angiographic findings. Results Compared with the non-CAD patients, CAD patients had significantly higher RDW-CV (P=0.009) and LP-PLA2 (P= 0.004) levels. The CAD patients with high Gensini scores had also significantly higher RDW-CV (P=0.001) and LP-PLA2 (P< 0.001) levels than those with low scores; RDW-CV and LP-PLA2 were significantly correlated with the Gensini score, and the area under curve of their combined detection was 0.931. Conclusion Combination of RDW and LP-PLA2 can improve the diagnostic accuracy of the degree of coronary artery stenosis in patients with CAD.