南方医科大学学报

南方医科大学学报 ›› 2016, Vol. 36 ›› Issue (03): 303-.

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猪抗人淋巴细胞球蛋白与兔抗人胸腺细胞球蛋白治疗重型再生障碍性贫血的疗效比较

杨楠，马肖容，张卉，曹星梅，陈银霞，何爱丽，刘捷，赵万红，张王刚   

  • 出版日期:2016-03-20 发布日期:2016-03-20

Therapeutic effects of porcine versus rabbit antithymocyte globulins for treatment of
severe aplastic anemia

  • Online:2016-03-20 Published:2016-03-20

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摘要： 目的比较猪抗人淋巴细胞球蛋白（ALG）与兔抗人胸腺细胞球蛋白（ATG）治疗重型再生障碍性贫血（再障）的疗效。方
法回顾分析2004~2013年接受免疫抑制治疗的重型再障患者（猪ALG组43例，兔ATG组32例）6个月有效率，χ2检验比较组间
差异。Kaplan-Meier 法绘制生存曲线，log-rank 检验比较组间差异。结果猪ALG组6 个月有效率为79.07%，高于兔ATG组
（56.25%）且差异显著（P=0.034）；5年总生存率为86.047%，高于兔ATG组（72.878%），但差异不显著（P=0.190）。结论猪ALG
血液学应答优于兔ATG，预后和安全性相似。

Abstract: Objective To compare the efficacy of porcine and rabbit antithymocyte globulins (ATG) in the treatment of severe
aplastic anemia (SAA). Methods We reviewed the clinical data of 43 SAA patients receiving porcine ALG treatment and 32
patients receiving rabbit ATG treatment between 2004 and 2013 in our hospital. The overall response rates of the patients at 6
month were compared, and the patients’ survival in the two groups was analyzed using Kaplan-Meier survival curves. Results
The overall response rates at 6 months was significantly higher in porcine ALG group than in rabbit ATG group (79.07% versus
56.25% , P=0.034). The 5-year overall survival was also higher in porcine ALG group than in rabbit ATG group, but this
difference was not statistically significant (86.047% versus 72.878%, P=0.190). Conclusions Porcine ALG is superior over rabbit
ATG in terms of hematological response but is comparable with rabbit ATG in view of the patients’ survival and safety.