南方医科大学学报

南方医科大学学报 ›› 2015, Vol. 35 ›› Issue (09): 1360-.

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海南汉族PLAG1 基因rs6474051 多态性与腮腺良性肿瘤的关联性

黄香，邱勋定，孙明磊，何升腾   

  • 出版日期:2015-09-20 发布日期:2015-09-20

Association of pleomorphic adenoma gene 1 polymorphism and benign parotid tumor in
Chinese Han population in Hainan Province

  • Online:2015-09-20 Published:2015-09-20

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摘要： 目的探讨海南汉族PLAG1基因rs6474051多态性与腮腺良性肿瘤的关联性。方法以65例海南汉族腮腺良性肿瘤患者
为实验组，69例正常体检者为对照，对所有入选者行PLAG1基因rs6474051多态性检测并行统计学分析。结果CC、CT、TT三
种基因型的检出例（率）在实验组中为33（50.8%）、25（38.5%）、7（10.7%），对照组中为44（63.8%）、24（34.8%）、1（1.4%），统计学分
析P=0.05。等位基因C/T 在两组中的检出率分别为70%/30%和80.6%/19.4%，组间差异具有统计学意义（P=0.023）。结论
PLAG1基因rs6474051多态性与海南人群腮腺良性肿瘤可能存在关联，等位基因T可能是其易感基因之一。

Abstract: Objective To investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1
(PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province. Methods Sixty-five patients with
benign parotid tumor and 69 healthy volunteers (control) were examined for Rs6474051 polymorphisms of PLAG1 gene by
PCR and sequencing. Results Of the 65 patients with benign parotid tumor, the frequencies of CC, CT, and TT genotypes were
33 (50.8%), 25 (38.5%), and 7 (10.7%), as compared to those of 44 (63.8%), 24 (34.8%), and 1 (1.4%) in the control group (P=0.05).
The allele frequency of C/T was 70%/30% in patients with benign parotid tumor, significantly different from that in the control
group (80.6%/19.4%, P<0.05). Conclusion Rs6474051 polymorphism of PLAG1 gene may be associated with the benign parotid
tumor in Chinese Han population in Hainan Province, and the T allele is probably one of susceptible genes.