南方医科大学学报

南方医科大学学报 ›› 2015, Vol. 35 ›› Issue (09): 1349-.

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TRPV4 在皮肤免疫性大疱病中的表达及意义

白洁，邹兴伟，姜友贵，王琼玉   

  • 出版日期:2015-09-20 发布日期:2015-09-20

Expression of transient receptor potential lvanilloidreceptor 4 protein in
autoimmune bullous skin disorders

  • Online:2015-09-20 Published:2015-09-20

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摘要： 目的探讨TRPV4蛋白在寻常型天疱疮（PV）、大疱性类天疱疮（BP）、疱疹样皮炎（DH）、获得性大疱性表皮松解症（EBA）中
的作用机制。方法用免疫组化方法检测正常皮肤组织、PV、BP、DH及EBA皮损组织中TRPV4蛋白的表达量。结果TRPV4在
PV（61.90%）、BP（81.81%）、DH（72.22%）、EBA（68.42%）的阳性率均低于正常皮肤组织（93.33%），且各类疾病间亦存在表达差
异（PV<EBA<DH<BP）。结论TRPV4蛋白的低表达可能影响着皮肤连接的形成或修复，参与皮肤免疫性大疱病的发生、发展。

Abstract: Objective To investigate the expression of transient receptor potential lvanilloidreceptor 4 (TRPV4) protein in
pemphigus vulgaris (PV), bullous pemphigoid (BP), dermatitis herpetiformis (DH), and epidermolysis bullosa acquisita (EBA),
and explore the role of TRPV4 in the pathogenesis of these diseases. Methods TRPV4 protein in normal skin tissues and
lesions of PV, BP, DH, and EBA were detected with immunohistochemistry. Results The positivity rate of TRPV4 protein
expression was 61.90% in PV, 81.81% in BP, 72.22% in DH, and 68.42% in EBA. TRPV4-positive rates in these lesions were
significantly lower than the rate in normal skin tissues (93.33%) and also differed significantly among these lesions (PV<EBA<
DH<BP). Conclusion Low TRPV4 expressions may affect the formation and reconstitution of skin connection. TRPV4 may
play an role in the occurrence and development of autoimmune bullous skin disorders.