南方医科大学学报 ›› 2015, Vol. 35 ›› Issue (01): 129-.
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平宝红,岳春燕,朱阳敏,高雅,吴彬,洪佳琼
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摘要: 目的学习总结利妥昔单抗(美罗华,RTX)相关的间质性肺炎(RTX-IP)的疾病特点、发病机制及诊疗方法。方法通过相关检查并结合文献回顾,对2例在使用RTX治疗过程中发生IP的淋巴瘤患者进行病例分析及治疗。结果2例患者在治疗后间质性肺炎病灶消失,后续原发病治疗过程顺利。结论RTX-IP起病隐匿,病理机制不明,症状不典型,需引起临床医生重视。高分辨CT对其早期发现应用价值高,RTX增加了患者对机会菌的易感性可能是部分患者的发病机制。
Abstract: We report two cases of rituximab (RTX)-induced interstitial pneumonia in two lymphoma patients receiving RTXtreatment. Interstitial pneumonia was successfully managed in these two cases after a one-week-long intervention withcorresponding treatments without affecting further treatment of the primary disease. RTX-induced interstitial pneumonia ischaracterized by a latent onset with an unclear pathological mechanism and absence of typical symptoms. High-resolution CTscan can provide valuable evidence for early diagnosis of RTX-induced interstitial pneumonia, which might be attributedpartially to an increased susceptibility to P. jirovecii and fungal infection due to prolonged RTX treatment.
平宝红,岳春燕,朱阳敏,高雅,吴彬,洪佳琼. 利妥昔单抗相关的间质性肺炎文献复习:附2例报告[J]. 南方医科大学学报, 2015, 35(01): 129-.
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