南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (09): 1286-.

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HSD11B2基因多态性与胎儿发育的关系

李健，王自能，董运鹏，陈丹，陈友鹏，卢永平，Hocher Berthold   

  • 出版日期:2014-09-20 发布日期:2014-09-20

Association between HSD11B2 gene polymorphism and fetal growth

  • Online:2014-09-20 Published:2014-09-20

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摘要： 目的探讨正常妊娠HSD11B2 基因多态性与胎儿发育的关系。方法用基因测序方法检测HSD11B2 启动子/G-209A、
G-194C、G-151A及G-126 A基因多态性。用PCR-毛细管电泳方法检测187对正常妊娠母血及脐血HSD11B2基因1号内含子
{CA}n微卫星多态性。结果1、本研究中33例汉族人群HSD11B2启动子/G-209A、G-194C、G-151A及G-126 A位点均为野生
型GG纯合子；2、新生儿出生体质量及孕晚期B超下体格参数指标在母血组和脐血组HSD11B2基因1号内含子{CA}n基因型
SS、SL、LL组或者SS+SL、LL组之间差异不显著（P>0.05）。在考虑分娩孕周、胎儿性别、孕妇孕前BMI、孕妇分娩体质量、年龄
为混杂因素的情况下, 母血及脐血HSD11B2基因1号内含子{CA}n基因型与新生儿出生体质量及孕晚期Ｂ超下胎儿体格参数
指标之间的关系，均未见相关性（P>0.05）。结论正常妊娠母体及胎儿HSD11B2基因多态性与胎儿发育指标不相关。

Abstract: Objective To explore the relationship between HSD11B2 polymorphisms and fetal growth during normal pregnancy.
Methods The HSD11B2 promoter/G-209A, G-194C, G-151A and G-126A genotypes were examined in 33 samples from Chinese
Han subjects by gene sequencing. HSD11B2 (CA)n microsatellite polymorphism in the first intron was detected in blood
samples from 187 maternal and newborn pairs by PCR-capillary electrophoresis. Results All the HSD11B2 promoter/G-209A,
G-194C, G-151A and G-126A genotypes were wild-type GG. The offspring birth weight and any ultrasound parameters
describing late gestational fetal body shape were not significantly different between maternal or fetal SS, SL and LL groups or
combined SS+SL and LL groups. When considering the relevant confounding factors (gestational age at delivery, newborn’s
gender, maternal body mass index before pregnancy, maternal weight at delivery and maternal age), the offspring birth weight
and late pregnancy ultrasound parameters were still not associated with the maternal or fetal HSD11B2｛CA｝n microsatellite
polymorphisms. Conclusion Fetal and maternal HSD11B2 polymorphism is not related to fetal growth during normal
pregnancy.