南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (09): 1291-.

• • 上一篇    下一篇

遗传与环境因素对双生子儿童执行功能的影响

胡小梅，马兴顺，朱文芬，傅一笑，周颖清，蒙华庆，侯枭，贾璐，覃青，王英诚，邓伟，李涛   

  • 出版日期:2014-09-20 发布日期:2014-09-20

Effect of hereditary and environmental factors on the executive function of twin children

  • Online:2014-09-20 Published:2014-09-20

PDF

1231

摘要： 目的探讨遗传与环境对双生子儿童执行功能的影响。方法用威斯康星卡片分类测验（Wisconsin Card Sorting Test,
WCST）中持续错误数指标评定重庆市122对6~18岁双生子的执行功能，通过OPEN-MX软件进行单因素结构方程模型的构
建，分析加性遗传因素、显性遗传因素及个体特殊环境因素对执行功能的影响。结果①在持续错误数总变异方差中显性遗传
占0.77（95% CI=0.65~0.84），个体特殊环境因素占0.23（95% CI=0.16~0.35）；②持续错误数与家庭功能、父亲和母亲健康均呈负
相关（r：-0.335，r：-0.335，r：-0.219，P<0.01），与父母养育方式和应激生活事件相关性不明显。结论持续错误数指标受显性遗传
和特殊环境因素的共同影响，而家庭环境中的家庭功能、父母健康状况对该指标的影响不容忽视。

Abstract: Objective To explore the influence of genetic and environmental factors on the executive function of twin children.
Methods The executive function of 122 twin pairs from Chongqing (aged from 6 to 18 years) were investigated with the
perseverative errors of the Wisconsin Card Sorting Test. Structural equation modeling was performed to evaluate the effects of
the additive genetic factors (A), dominance genetic latent factors (D) and individual specific environmental factors (E) on the
executive functions. Results The effects of D and E on perseverative errors were 0. 77 (95%CI: 0.65-0.84) and 0.23 (95%CI:
0.16-0.35), respectively. The probability of perseverative errors showed a significant negative correlation with family
functioning and with the total GHQ-12 scores of the fathers and mothers (r:-0.335, -0.335, and -0.219, respectively, P<0.01).
Perseverative errors were not significantly correlated with the parenting styles and stress life events. Conclusion Perseverative
errors are influenced by a common dominance genetic latent factor and individual specific environmental factors, but the role
of environmental factors such as family functioning and parental health can not be ignored.