Abstract: Objective To explore the effect of mindfulness meditation training for improving anxiety, depression and sleep disorders in perimenopausal women. Methods Intervention by menopause meditation training was delivered in 121 perimenopausal women with anxiety, depression or sleep disorders in Baiyun District, Guangzhou. Before and after the intervention, the Self-rating Anxiety Scale, Self-rating Depression Scale and Pittsburg Sleep Quality Index were used for assessment of changes in the conditions of the women. Results After menopausal meditation training, the perimenopausal women showed significant improvement in the mean scores of Self-rating Anxiety Scale (48.26 ± 6.47; t=3.865, P<0.01), Selfrating Depression Scale (50.27 ± 6.54; t=4.541, P<0.01) and Pittsburgh Sleep Questionnaire (10.64 ± 4.38; t=5.596, P<0.01). The symptom remission rates differed significantly among the women with different self-practice frequencies (P<0.01). The remission rates of anxiety, depression and sleep disorder increased significantly with the frequency of self-exercise (P<0.01). Conclusion Mindfulness meditation training can effectively alleviate the symptoms of anxiety and depression and improve the quality of sleep in perimenopausal women, and the frequency of the exercise is positively correlated with the improvements. Mindfulness meditation training can be an effective intervention for improving the mental health of perimenopausal women.