南方医科大学学报

南方医科大学学报 ›› 2019, Vol. 39 ›› Issue (05): 609-.doi: 10.12122/j.issn.1673-4254.2019.05.18

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血浆干扰素诱导蛋白10 在不同受累范围肺结核患者血浆中的表达

董海平，刘志辉，梁小成，简奕娈，李德宪，劳穗华，梁锋，潘燕珊，邝小佳   

  • 出版日期:2019-05-20 发布日期:2019-05-20

Plasma levels of interferon-inducible protein 10 in patients with active pulmonary tuberculosis with different affected areas

  • Online:2019-05-20 Published:2019-05-20

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摘要： 目的探讨干扰素诱导蛋白10（IP-10）在活动性肺结核辅助诊断及判断病情严重程度方面的参考价值。方法选择本院 2013年2月~2017年2月健康体检者84例为对照组及住院肺结核患者193例为结核组，应用液相芯片Luminex技术检测观察对 象血浆中IFN-γ和IP-10细胞因子的表达量。将结核组根据病灶范围所占面积可继续分为A组（1~2个肺野）、B组（3~4个肺野） 和C组（5~6个肺野），比较3组患者IFN-γ和IP-10的表达差异。结果结核组患者血浆中IP-10的表达高于对照组，差异有统计 学意义（P<0.05），而两组间IFN-γ的差异无统计学意义（P>0.05）；IP-10在C组明显随病灶增多而升高，与其他组的差异有统计 学意义（P<0.05），而IFN-γ在各组之间差异无统计学意义（P>0.05）。结论血浆IP-10对活动性肺结核的辅助诊断及病情严重程 度的判断方面是具有一定的参考价值。

Abstract: Objective To explore the value of interferon-inducible protein 10 (IP-10) in the auxiliary diagnosis of tuberculosis and the judgment of the severity of disease. Methods From February, 2013 to February, 2017, a total of 193 patients with TB admitted in our hospital and 84 healthy control subjects were recruited consecutively. The peripheral blood plasma levels of interferon-γ (IFN-γ) and IP-10 were detected using liquid phase chip (Luminex) technique. According to the number of lung fields affected by TB, the patients were divided into group A (with lesions in 1-2 lung fields), group B (3-4 lung fields) and group C (5-6 lung fields), The expressions of IFN-γ and IP-10 in 3 groups were compared. Results The plasma levels of IP-10 were significantly higher in TB patients than in the control subjects (P<0.05), but IFN-γ levels were comparable between the two groups (P>0.05). Among the TB patients, plasma IP-10 levels was the highest in group C (P<0.05), and IFN-γ levels did not differ significantly among the 3 groups (P>0.05). Conclusion Plasma IP-10 has a certain reference value in the auxiliary diagnosis of active tuberculosis and the judgment of the severity of the disease.