To comprehensively investigate the potential impact of interleukin-10 (IL-10) overexpression on macrophage polarization and their targeting capabilities towards atherosclerotic plaques through transcriptome sequencing and ex vivo tissue imaging techniques.

Transcriptome sequencing and differential gene analysis were performed after infecting macrophages with a lentivirus to induce overexpression of IL-10 (IL-10M). The changes in expression levels of macrophage polarization markers were validated using RT-qPCR and flow cytometry. Subsequently, ApoE-/- mice were intravenously administered IL-10M and ConM via the tail vein after being fed a Western diet, and the targeting efficiency of cells towards aortic plaques was assessed through ex vivo and histological fluorescence imaging.

Transcriptomic analysis revealed that there were 1271 differentially expressed genes in IL-10M compared to the control group (ConM). The IL-10M group exhibited significant expression changes in several key genes associated with macrophage polarization. M1 phenotype markers Cd86 and tumor necrosis factor (Tnf) exhibited downregulation, while Il-1beta demonstrated upregulation in IL-10M; M2 phenotype marker mannose receptor 1 (Mrc1) displayed upregulation, whereas arginase-2 (Arg2) showed downregulation. RT-qPCR confirmed the expression of Mrc1, Tnf-alpha, and Il-1beta in IL-10M, consistent with the sequencing results. Furthermore, flow cytometry revealed a reduction in CD86 expression levels in IL-10M compared to ConM. After intravenous injection, fluorescence signals of IL-10M and ConM can be respectively observed at the site of atherosclerotic plaque in mice aorta.

The overexpression of IL-10 modulated the expression of markers associated with macrophage polarization while preserving their targeting ability towards plaques. This discovery establishes a scientific foundation for further investigation into the potential role of IL-10 in preventing and treating atherosclerosis, thereby supporting the development of novel anti-inflammatory therapeutic strategies.

To investigate the correlation between ^99mTc-c(RGD)₂ SPECT/CT and ¹⁸F-FDG PET/CT imaging on the expression of neovascularization in the infiltration zone of hepatic alveolar echinococcosis (HAE).

A prospective study was used to collect the data of 34 patients with HAE admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2023 to January 2024. All patients underwent whole-body ¹⁸F-FDG PET/CT, abdominal ^99mTc-c(RGD)₂ SPECT/CT imaging and surgical treatment. Routine HE staining and CD34 immunohistochemical staining were performed on 41 HAE tissues, and microvascular density (MVD) counts in the infiltration zone were measured. Analyze the correlation between maximum standardized uptake value (SUV_max), tumor to background ratios (TBR), target to nontarget ratio (T/NT)and MVD counts in the infiltration zone of HAE, respectively; Compare the differences in MVD counts in the HAE infiltration zone between the ^99mTc-c(RGD)₂ SPECT/CT imaging positive (T/NT > 1) and negative (T/NT < 1) groups.

In the ^99mTc-c(RGD)₂ SPECT/CT imaging, there was a high positive correlation (r=0.823, P < 0.01) between the T/NT values and MVD counts in 41 HAE lesion infiltration zones; Compared with ¹⁸F-FDG PET/CT imaging, SUV_max value and TBR were not correlated with MVD count, respectively (P > 0.05).The MVD counts in the ^99mTc-c(RGD)₂ SPECT/CT imaging positive group of 17 and negative group of 24 AE lesions were 89.00±9.87 and 43.08±18.36/ high magnification field, and the difference between the two groups was statistically significant (P < 0.05).

In the ^99mTc-c(RGD)₂ SPECT/CT imaging, the degree of RGD uptake is highly positively correlated with the amount of neovascularization in the infiltrating zone of HAE, ^99mTc-c(RGD)₂ SPECT/CT imaging can indirectly reflect the invasiveness of liver AE, and can be used as one of the economic and non-invasive diagnostic methods to evaluate the invasiveness of lesions. It can also be combined with ¹⁸F-FDG PET/CT to evaluate its biological activity from both the expression of neovascularization and inflammatory activity in the infiltrating zone of HAE.

To evaluate the worth of intra-tumoral and peri-tumoral radiomics Nomogram in the pre-operative prognostication of axillary lymph node (ALN) metastasis based on digital breast tomosynthesis (DBT) for breast cancer.

A total of 210 breast cancer patients performed breast DBT examinations were retrospectively collected at the First Affiliated Hospital of Bengbu Medical University from January 2019 to December 2023, all patients were stochastically allocated to a training set (n=147) and a verification set (n=63) in a 7:3 ratio. Select the largest dimension of the tumor in the DBT image to manually delineate the ROI of the intra-tumoral region of interest, and the peri-tumoral ROI was obtained by expanding outward by 3 mm. Radiomics features were extracted and screened. Support vector machine was used to construct the models of intra-tumoral, peritumoral and intra-tumoral + peri-tumoral and calculate predictions. The predicted value of the radiomics model with the highest predictive efficiency was selected, and a Nomogram model was created by combining the clinical features. The forecast power of the model was analyzed using the ROC curve, calibration and decision curves.

The "intra-tumoral+peri-tumoral" model constructed from the 15 best radiomics features performed better than the "intra-tumoral" and "peri-tumoral" models. ALN palpation, DBT_ALN and "intra-tumoral + peri-tumoral" model's forecast value are separate risk elements (P < 0.05), and the best predictive efficacy was achieved by the constructed Nomogram model, with sensitivity of 82.7%, specificity of 94.7%, accuracy of 86.4%, AUC of 0.942 in the training set, and 0.932, 90.5%, 83.3% and 87.3% in the verification set.

The Nomogram incorporating intra-tumoural and peri-tumoural DBT radiomics characteristics and clinical elements are effective in predicting ALN metastasis before the operation of breast cancer, regarding as a noninvasive predictive approach to assist clinical policy development.

To investigate the value of diagnosing non-alcoholic fatty liver disease (NAFLD) based on MRI and US radiomics-clinical combined model.

The MRI and US images of 207 patients, including 89 NAFLD patients and 118 non-NAFLD patients from the Affiliated Hospital North of Medical College from March 2021 to September 2023 were retrospectively analyzed and randomly divided into a training set (n=165, 71 cases of NAFLD and 94 cases of non-NAFLD) and a test set (n=42, 18 cases of NAFLD, 24 cases of non-NAFLD). Independent clinical predictors of NAFLD were screened by univariae ad multivariate Logistic regression analysis. Then clinical models were established. Based on the OP-IP sequence in MRI and US images, we extracted and screened the radiomics features and established the radiomics models, which were MRI radiomics model, US radiomics model and MRI-US radiomics combined model. The MRI radiomics-clinical combined model, US radiomics-clinical combined model and MRI-US radiomics-clinical combined model were established by combining the clinical features and radiomics features; the efficacy of each model in the diagnosis of NALFD was evaluated by using the ROC curves of the subjects, and the clinical value of each model was evaluated by using the decision curve analysis.

AFP, VLDL-C and mental disease were clinically independent predictors of NAFLD. At the same time, clinical model was established. Based on MRI, ninteen radiomics features were screened out, and based on US images, sixteen radiomics features were screened out. Meanwhile, the radiomics features of filtering out were used to establish MRI radiomics model, US radiomics model and MRI-US radiomics combined model. Clinical features and the best radiomics features were combined, which were used to build MRI radiomics-clinical combined model, US radiomics-clinical combined model, and MRI-US radiomics-clinical combined model. In the training set, the AUC of the clinical model, the MRI radiomics model, the US radiomics model, the MRI-US radiomics combined model, the MRI radiomics-clinical combined model, the US radiomics-clinical combined model, the MRI-US radiomics-clinical combined model for making a diagnose of NAFLD were 0.99, 1.00, 0.99, 1.00, 1.00, 0.99, 1.00. In the test set, they were 0.94, 1.00, 0.89, 0.99, 1.00, 0.98, 1.00. The results of the DCA showed the highest efficacy of the MRI-US radiomics-clinical combined model in the training set and test set.

The MRI-US radiomics-clinical combined model based on MRI and US has high diagnostic value for NAFLD.

To investigate the changes in voxel-mirrored homotopic connectivity (VMHC) in bilateral cerebral hemispheres of patients with primary dysmenorrhea (PDM), as well as the changes in VMHC before and after acupuncture treatment, and the changes of VMHC before and after acupuncture treatment, using resting-state functional magnetic resonance imaging, and to analyze the correlation between VMHC value and clinical scale scores before and after acupuncture treatment in PDM group.

Fifty-eight patients with PDM in Shaanxi University of Chinese Medicine from September 2021 to September 2022 were prospectively included as the PDM group, and 50 healthy subjects from the same period were selected as the healthy control group. Resting-state functional magnetic resonance imaging scan was performed on the 1st to 3rd day of menstruation. The visual analogue scale (VAS), COX dysmenorrhea symptom scale (CMSS), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were completed. The PDM group received continuous acupuncture therapy at Sanyinjiao and Guanyuan point one week before the next menstrual period. There were 30 cases in PDM group participating in complete acupuncture. Independent samples t-test and paired t-test were performed using VMHC method and DPABI software based on Matlab platform to observe the brain regions with differences in VMHC values between the two groups of subjects and PDM group before and after acupuncture treatment. Spearman correlation analysis was finally applied. The correlation between VMHC value and clinical scale score before and after acupuncture treatment in PDM group was observed.

There were substantial variances in VAS, CMSS, SAS and SDS scores between PDM group and healthy control group (P < 0.001). Substantial variations were also observed in VAS, CMSS, SAS, and SDS scores before and after acupuncture therapy in the PDM group (P < 0.01). Compared to the healthy control group, the brain regions with increased VMHC value in PDM group mainly included bilateral posterior cingulate cortex, fusoid gyrus, superior temporal gyrus / middle temporal gyrus and putamen, while bilateral prefrontal cortex had decreased VMHC value (voxel level P < 0.001, group level P < 0.05). The VMHC value in the medial cingulate brain and suboccipital gyrus of the PDM group reduced following acupuncture. The decrease in VMHC value in the bilateral suboccipital gyrus following acupuncture in the PDM group was favorably associated with the change of CMSS total seizure time scale score (r=0.398, P < 0.05).

Based on resting state functional magnetic resonance imaging and VMHC method, there are likely homotopy functional connectivity problems in the symmetrical brain regions between the bilateral cerebral hemispheres in PDM patients. Acupuncture had a beneficial clinical effect on PDM patients, decreasing the VMHC levels of both the medial cingulate cortex and the suboccipital gyrus. These abnormal brain areas are primarily situated in pain transmission pathways and may play a role in acupuncture's central analgesic mechanism in the treatment of primary dysmenorrhea.

To investigate the value of strain elastography combined with thyroid imaging reporting and data system (TIRADS) in the differential diagnosis of benign and malignant thyroid nodules.

A total of 82 patients with thyroid nodules who were treated in the Third Affiliated Hospital of Xuzhou Medical University from January 2020 to January 2023 were selected. All patients underwent strain ultrasound elastography and TIRADS score. With pathological examination as the gold standard for diagnosis, the subjects were divided into malignant group (n=8) and benign group (n=74). Logistic regression model was used to screen the independent predictors of malignant thyroid nodules. ROC curve was used to evaluate the efficacy of strain elastography, elastic strain ratio (SR), TIRADS score and their combination in the diagnosis of benign and malignant thyroid nodules.

There were significant differences in strain ultrasound elastography score, SR and TIRADS score between the two groups (P < 0.05). Multivariate Logistic regression analysis showed that strain ultrasound elastography score, SR and TIRADS score were independent predictors of malignant thyroid nodules, with OR values of 1.675, 1.550 and 1.476, respectively (P < 0.05). ROC curve analysis showed that the area under the curve of strain ultrasound elastography score, SR, TIRADS score and the combination of the three in the diagnosis of malignant thyroid nodules were 0.794, 0.919, 0.875, 0.994, respectively, and the combination of the three had the highest diagnostic value (P < 0.001).

Strain elastography and TIRADS have certain value in the differential diagnosis of benign and malignant thyroid nodules. The combination of the two methods can improve the diagnostic efficiency.

To analyze the relationship and correlation between ultrasonography and contrast-enhanced ultrasound features and the expression of B7-H4 in invasive ductal carcinoma (IDC).

A total of 136 female patients admitted to the Department of Breast Surgery, First Affiliated Hospital of Xinjiang Medical University from January 2015 to January 2021 were retrospectively analyzed. Following surgical resection, specimens were histopathologically confirmed as IDC. Immunohistochemistry was utilized to detect the expression of B7-H4 in the cell membrane and cytoplasm of breast cancer cells from the pathological specimens. Prior to surgery, all patients underwent two-dimensional ultrasound and contrast-enhanced ultrasound of the breast. Ultrasound and contrast-enhanced ultrasound characteristics of the lesions were documented, and their correlation with the expression level of B7-H4 in IDC was subsequently analyzed.

The expression of B7-H4 in the cell membrane and cytoplasm of breast cancer cells was detected by immunohistochemistry in 136 patients. Due to the high temperature during antigen repair or other reasons, 2 pieces of tissue were removed. Among the remaining 134 sections, 6 were negative expression and 128 were positive expression, including 85 high expression and 43 low expression. In different B7-H4 expression groups, when B7-H4 was highly expressed, the two-dimensional ultrasound of IDC mass was prone to characteristics such as aspect ratio>1, irregular shape, interruption of surrounding tissue echo, posterior echo attenuation, lymph node metastasis (P<0.05); The characteristics of IDC contrast-enhanced ultrasound were prone to the characteristics of internal filling defect and peripheral convergence sign after enhancement (P<0.05). The high expression of B7-H4 was positively correlated with the two-dimensional ultrasound features such as tumor morphology, aspect ratio, posterior acoustic attenuation and surrounding tissue echo in two-dimensional IDC ultrasound (r=0.188, 0.240, 0.185, 0.344, P<0.05).

IDC ultrasound and contrast-enhanced ultrasound findings have a certain correlation with the expression of B7-H4. The characteristics of IDC ultrasound and contrast-enhanced ultrasound can predict the expression of molecular marker B7-H4 in IDC, and then provide a reliable imaging reference for the evaluation of the possible B7-H4 targeted therapy effect of breast cancer.

To establish the evaluation criteria of experimental rheumatoid arthritis by micro-CT and high-frequency ultrasound.

Five IL-1β knockout mice with spontaneous arthritis and five SD rats with rheumatoid arthritis (CIA) induced by bovine type Ⅱ collagen were constructed. Then, the toes of arthritis model mice were imaged by micro-CT, and the microscopic parameters such as BV/TV and BS/TV were analyzed. High-frequency ultrasound was used to image the knee joint of arthritis model mice to detect the echo intensity of the knee joint and observe whether there was effusion in the knee joint.

Micro-CT could clearly detect the enlargement and deformity of the toes in the arthritis model mice, and the microscopic parameters BV/TV and BS/TV were significantly reduced. High-frequency ultrasound could clearly observe the knee joint effusion in arthritis model mice, and the echo intensity of knee joint gray value quantitative response in arthritis model group was significantly lower than that in control group.

The application of micro-CT and high-frequency ultrasound imaging analysis of small animal toes and knees can systematically evaluate the development of experimental rheumatoid arthritis, and compensate for the lack of unified standards in experimental rheumatoid arthritis imaging.

To investigate the predictive value of multi-slice spiral CT (MSCT) for invasive lung adenocarcinoma with the new version of the three-stage stratification system.

The clinical, MSCT and pathological data of 120 patients with pathologically confirmed invasive lung adenocarcinoma admitted to the Cardiothoracic Surgical Ward of the First Affiliated Hospital of Jiamusi University from July 2022 to September 2023 were retrospectively collected, and the cases were classified into the highly differentiated group (predominantly adherent type, and the high-grade component<20%, n=17), the moderately differentiated group (predominantly acinar / nipple type, and the high-grade component<20%, n=61), and the low-differentiated group (any subtype and high-grade component ≥20%, n=42). The relationship between MSCT signs and the degree of differentiation in the three groups was analyzed and compared among the three groups of patients.

The results of univariate analysis showed that there was no statistically significant difference in age, gender and smoking history among the three groups (P>0.05). The differences in diameter, lesion type, lobulated sign, spinous process sign, air-containing cavities, air bronchogram sign, obstructive emphysema, changes of vessels, and lymphadenectasis between the low-differentiated group and the moderately-and highly differentiated groups were statistically significant (P<0.05), and the differences in the number and shape of the lesions, and the spicule sign, calcification and pleural traction sign were not statistically significant (P>0.05). The results of multivariate ordered Logistic regression analysis showed that diameter (OR= 1.093, P=0.001) and lesion type (OR=0.308, P=0.033) were risk factors for low-differentiated in the latest IASLC tertiary stratification system for lung adenocarcinoma.

MSCT has a predictive value for the latest IASLC tertiary stratification system of invasive lung adenocarcinoma, which can guide the clinic to formulate a treatment plan for patients in line with individualization.

To evaluate the glymphatic system function in patients with newly diagnosed type 2 diabetes mellitus (T2DM) by using diffusion tensor image analysis along the perivascular space (DTI-ALPS), and to explore the relationship with insulin resistance of homeostasis model (HOMA-IR).

A total of 30 patients with newly diagnosed T2DM, clinically diagnosed at the Affiliated Hospital of Xuzhou Medical University from April to June 2023, were selected as the newly diagnosed T2DM group. Additionally, 30 healthy individuals who underwent physical examinations at the hospital and were matched with the newly diagnosed T2DM group in terms of age and gender were selected as the control group. The clinical indicators of the subjects were collected, including glycosylated hemoglobin (HbA1c) (%), fasting blood glucose (mmol/L), and fasting insulin (pmol/L) levels. The homeostasis model assessment (HOMA-IR) index of insulin resistance was calculated. Sixty subjects were scanned by a 3.0T MRI, and the ALPS index was calculated to compare the differences between the two groups. Pearson correlation was used to analyze the correlation between HOMA-IR and ALPS index in the newly diagnosed T2DM group.

Significant differences were observed in fasting plasma glucose, fasting insulin, glycosylated hemoglobin, and HOMA-IR between the two groups (P < 0.05). The ALPS index was significantly decreased in the newly diagnosed T2DM group (1.50±0.22 vs 1.31±0.18, P < 0.001) and was negatively correlated with HOMA-IR (r=-0.622, P < 0.001).

The DTI-ALPS index can be used to evaluate the glymphatic system function in patients with newly diagnosed T2DM, and the decline in glymphatic system function is related to insulin resistance.

To analyze the clinical and imaging features of pulmonary cryptococcal infection complicated with AIDS, so as to improve the cognition of the disease.

The clinical and imaging features of 54 patients with AIDS complicated with cryptococcal pneumonia were analyzed retrospectively from May 2019 to December 2020, including 38 males and 16 females, with an average age of 19-73(38.2±19.98) years old.

Among the 54 patients, CD4 count ranged from 13 to 198 cells/μL, with a median of 42 cells/μL. Clinical features: 8 cases (14.3%) were asymptomatic, 37 cases (68.5%) had fever, 38 cases (70.4%) had cough, 37 cases (68.5%) had expectoration, 28 cases (51.9%) had chest pain, 40 cases (74.1%) had headache, 6 cases (11.1%) had nausea and vomiting, 5 cases (9.3%) had disturbance of consciousness, and 40 cases (74.1%) had cryptococcal meningitis. Lesion distribution: 6 cases had single lesions (11.1%), 48 cases had multiple lesions (88.9%), involving the upper lobe in 33 cases (61.1%), the middle lobe in 18 cases (33.3%), and the lower lobe in 36 cases (66.7%). Imaging features: nodules or masses were present in 39 cases (72.2%), with single nodules in 6 cases (11.1%), multiple nodules in 33 cases (61.1%), masses in 3 cases (5.6%), intranodular cavitation in 6 cases (11.1%), halo sign around nodules in 3 cases (5.6%), spiculation in 12 cases (22.2%), ground-glass opacity in 6 cases (11.1%); consolidation in 21 cases (37.5%); effusion in 20 cases (35.7%); cavitation in 36 cases (66.7%), with thick-walled cavities in 6 cases (11.1%) and thin-walled cavities in 30 cases (55.6%); interstitial reticular opacity in 15 cases (27.8%); mediastinal lymphadenopathy in 15 cases (27.8%); hilar lymphadenopathy in 13 cases (24.1%); pleural effusion in 0 cases (0%); mixed lesions in 45 cases (83.3%).

Clinical symptoms of AIDS-related pulmonary cryptococcosis are mainly fever, cough, and sputum production, with most patients having CD4 counts below 200 cells/μL; imaging findings exhibit certain characteristics, with multi-lobed and multifocal lesions being common, along with nodules, thin-walled cavities, consolidation, and ground-glass opacity; pleural effusion is extremely rare.

To explore the value of CT angiography (CTA) combined with multimodal MRI in evaluating the ischemic penumbra (IP) and collateral circulation in acute ischemic stroke (AIS) and its application in prognostic assessment.

Fifty-seven cases of AIS patients diagnosed from January 2019 to January 2022 at our hospital were retrospectively collected, with the age of 36-78 (63.4±12.3) years old. All patients underwent multimodal MR combined with CTA examination, and the MRI data, CTA data and clinical data were collected. Cerebral collateral circulation and IP were diagnosed through CTA combined with 3D-TOF-MRA. The factors affecting IP, perfusion-diffusion mismatch and therapeutic efficacy were analyzed by intergroup comparison.

30 cases (52.6%) in the IP group, and 27 cases (47.4%) in the non-IP group. The difference was statistically significant (P<0.05). The grade of collateral circulation was negatively correlated with the volume of infarct area and hypoperfusion area on admission (r=-0.603, -0.331, P<0.01), and positively correlated with perfusion-diffusion mismatch (r=0.528, P<0.001). There were 37 patients (64.9%) with good collateral circulation and 20 patients (35.1%) with poor patency. The proportP<0.05). The improved value of NIHSS score, perfusion-diffusion mismatch, and collateral circulation grades in the significant effect group were significantly better than those in the insignificant effect group (P<0.05).

CTA combined with multimodal MRI is helpful to evaluate the changes of cerebral blood flow in patients with AIS, and the accurate assessment of collateral circulation and IP can effectively predict the short-term curative effect of AIS.

To investigate the feasibility of utilizing virtual non-contrast enhanced (VNC) images derived from dual-energy computed tomography (DECT) for the assessment of part-solid nodules (PSN) within the lung, and compare the image quality with that of true non-enhanced (TNC) images.

A retrospective analysis was conducted on 46 patients with solitary pulmonary nodules at our institution from January 2022 to January 2023. Patients underwent both TNC scanning and contrast-enhanced DECT scanning during the arterial and venous phases, with dual-phase VNC images reconstructed from the dual-phase DECT data. CT values, noise (standard deviation), and lesion diameters of PSN and the ipsilateral erector spinae muscle were measured on both dual-phase VNC and TNC images. The signal-to-noise ratio and contrast-to-noise ratio for PSN were calculated. Effective radiation doses in TNC and VNC modes were recorded. Subjective scoring was performed by two experienced radiologists using a 5-point scale. Non-parametric tests were employed to compare the subjective and objective parameters, as well as the effective radiation doses, of images obtained at different scanning phases. Kappa tests were utilized to evaluate the inter-rater agreement of the subjective scores provided by the two radiologists.

The objective evaluation metrics (diameter, CT value, standard deviation, signal-to-noise ratio, contrast-to-noise ratio) between arterial and venous phase VNC and TNC images were not statistically significant (P > 0.05). The mean subjective score for TNC images was the highest, followed by venous phase VNC images, with arterial phase scores being the lowest. There was a statistically significant difference in the scores among the three groups (P < 0.001), yet both phases of VNC met diagnostic requirements. The inter-rater agreement for the subjective scores between the two radiologists was strong, with a range of 0.63 to 0.73. The use of VNC in place of TNC resulted in an approximate 30% reduction in radiation dose.

The dual-phase spectral CT with virtual non-contrast venous phase imaging provides image quality comparable to conventional non-contrast imaging and significantly reduces patient radiation exposure, making it particularly suitable for patients requiring multiple follow-up examinations.

To analyze the effects of 3.0T diffusion-weighted magnetic resonance imaging (MRI-DWI) guided laparoscopic surgery at different time in the treatment of pelvic abscess.

Sixty patients with pelvic abscess who were admitted to Suzhou First People's Hospital (Suzhou Branch of the Tenth People's Hospital Affiliated to Tongji University) from January 2020 to December 2023 were divided into the control group (n=30) and the observation group (n=30) using the random number table method. Patients in control group received MRI-DWI examination within 1-7 d of antibiotic therapy, and those with acute pelvic abscess confirmed by MRI-DWI were treated with laparoscopic surgery. Patients in observation group received MRI-DWI examination within 7-14 d of antibiotic therapy, and those with chronic pelvic abscess were treated with laparoscopic surgery. Laparoscopic histopathological manifestations, clinical cure rate, salpingectomy rate, operation, tubal patency rate during the follow-up period and recurrence rate of pelvic inflammatory disease were compared between the two groups.

No conversion to laparotomy occurred in either group. Preoperative MRI staging was consistent with laparoscopic findings. The cure rate was 100% in both groups. There was no statistically significant difference in salpingectomy rate (P > 0.05). Operation time, postoperative exhaust time, intraoperative blood loss and incidence of complications in observation group were significantly shorter or less than those in control group (P < 0.05). The tubal patency rate in observation group was significantly higher than that in control group and recurrence rate of pelvic inflammatory disease was significantly lower than that in control group (P < 0.05).

3.0T MRI-DWI is helpful for selecting the timing of surgery for gynecological pelvic abscess. Laparoscopic surgery is more effective for patients with chronic pelvic abscess confirmed by MRI-DWI after antibiotic therapy.

To analyzed the sonographic imaging profile of subcapsular hepatic tuberculosis abscesses (SHTB).

The present study retrospectively evaluated sonographic imaging features of 61 SHTB cases, and their sonographic findings were classified based on the degree of involvement to the liver capsule. Concomitant abdominal tuberculosis involvement was assessed.

Among the 61 patients, 59 case (96.7%) presented fusiform lesions; with the most common location being in diaphragm dome of the right lobe. In 57 cases (93.5%), the lesions exhibited hypoechoic areas internally, and in 30 cases (49.2%), there was evidence of liquefaction within the lesions, while only 6 cases showed calcification. Furthermore, 50 cases (82.0%) had type Ⅰ capsules with continuous integrity, whereas 11 cases (18.0%) had type Ⅱ capsules with discontinuity. Additionally, abdominal effusion was present in 22 patients (36.1%).

The ultrasound presentation of SHTB is characteristic, mostly occurring in the diaphragm dome of the right lobe, and the lesions are predominantly fusiform, often accompanied by a history of tuberculous peritonitis. Inside the lesion, there were mostly hypoechoic areas, and most of the peritoneum was intact. Ultrasound is a common imaging test for diagnosis and follow-up in patients with clinical suspicion of tuberculous hepatic peritoneal abscesses.