Abstract: Objective To investigate the expression of transient receptor potential lvanilloidreceptor 4 (TRPV4) protein in
pemphigus vulgaris (PV), bullous pemphigoid (BP), dermatitis herpetiformis (DH), and epidermolysis bullosa acquisita (EBA),
and explore the role of TRPV4 in the pathogenesis of these diseases. Methods TRPV4 protein in normal skin tissues and
lesions of PV, BP, DH, and EBA were detected with immunohistochemistry. Results The positivity rate of TRPV4 protein
expression was 61.90% in PV, 81.81% in BP, 72.22% in DH, and 68.42% in EBA. TRPV4-positive rates in these lesions were
significantly lower than the rate in normal skin tissues (93.33%) and also differed significantly among these lesions (PV<EBA<
DH<BP). Conclusion Low TRPV4 expressions may affect the formation and reconstitution of skin connection. TRPV4 may
play an role in the occurrence and development of autoimmune bullous skin disorders.