Abstract: With the development of high-throughput technologies, biomedical data has been increasing exponentially in an
explosive manner. This brings enormous opportunities and challenges to biomedical researchers on how to effectively utilize
big data. Big data is different from traditional data in many ways, described as“3Vs”- volume, variety and velocity. From the
perspective of biomedical research, here I introduced the characteristics of big data, such as its messiness, re-usage and
openness. Focusing on microbiome research of meta-analysis, the author discussed the prospective principles in data
collection, challenges of privacy protection in data management, and the scalable tools in data analysis with examples from
real life