Abstract: Objective To investigate the effect of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions.
Methods With Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum as the testing bacteria, the minimal
inhibitory concentration (MIC) of cetylpyridinium chloride buccal tablets was determined using minute amount serial dilution
test. The production of volatile sulfur compounds (VSCs) was measured using sulfide detector halimeter in the anaerobic
bacteria culture at 4 and 8 h after addition of the tablets. The effect of the tablets in suppressing odor production by
mouth-borne halitosis bacteria was assessed using cysteine challenge test in healthy volunteers, and the effectiveness was
evaluated by measuring the reduction in VSCs production and the duration of the effect. Results Cetylpyridinium chloride
buccal tablets inhibited the growth of all the 3 bacteria. The tablets obviously inhibited VSCs production by the 3 bacteria with
a effect similar to chlorhexidine. Compared with distilled water gargle, the buccal tablets significantly reduced
cysteine-induced VSCs production level in the healthy volunteers (P<0.05), and the effect lasted for 230 min. Conclusion
Cetylpyridinium chloride tablets can obviously suppress bacteria responsible for oral halitosis and produce good effects in the
treatment of halitosis induced by oral conditions.