Abstract: Objective To study the value of the biochemical markers heart fatty acid binding protein (H-FABP), creatine kinase
isoenzyme-MB (CK-MB), myocardial troponin T (cTnT) in early diagnosis of acute myocardial infarction (AMI). Methods
Serum levels of H-FABP, CK-MB, and cTNT were detected in 95 patients with confirmed AMI at different time points
following the onset in comparison with the data from 43 patients without AMI. The sensitivity and specificity of H-FABP in
different phases following the onset were compared between those of CK-MB and cTnT. Results Serum H-FABP activities
increased significantly within 3 h after the onset of AMI (P<0.01) and continued to increase at 3-6 h and 6-12 h (P<0.001). Serum
level of CK-MB within 6 h and cTnT level within 3 h after AMI onset did not show obvious changes (P<0.05). Both the
diagnostic sensitivity and specificity of H-FABP within 3 h and within 3-6 h were higher than those CK-MB and cTnT (P<0.05).
Conclusion H-FABP is superior to CK-MB and cTnT in early diagnosis (within 3 h and 3-6 h following the onset) of AMI.