Abstract: Objective To study the inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1
influenza viruses. Methods The lead compound was structurally modified to obtain 3 compounds with inhibitory activities
against H5N1 influenza viruses. Specs compound librany was screened and 4 compounds were identified to have such
inhibitory activities. The inhibitory activities of these compounds were tested at a celluar level against H5N1 influenza viruses.
Results and Conclusion The compounds 1a, 1b, 1e and 1f showed signifcant inhibitory activities against the entry of A/AnHui/
1/2005 pseudovirus into the target cells with an IC50 value of 4.7±0.3 μmol/L.