Abstract: Objective To evaluate the diagnostic value of ultrasonography in combination with mammography for breast cancer
within 2 cm. Methods The PubMed, the Cochrane Library, CNKI, CBM and Wanfang databases (2003/01/01-2013/04/30) were
searched for studies of the diagnostic value of ultrasonography in combination with mammography for breast cancer within 2
cm. The quality of the included studies was evaluated according to QUADAS items. The pooled sensitivity (SEN), pooled
specificity (SPE), pooled diagnostic odds ratio (DOR), and area under summary receiver operating characteristic curve (AUC)
were calculated using Review Manager 5.2 and Meta-DiSc 1.4 software. Results Nine articles were included in the final
analysis. The pooled SEN of ultrasonography, mammography and their combination were 0.75, 0.66, and 0.92, the pooled SPE
0.75, 0.83, and 0.82, the pooled DOR 7.11, 8.67, and 60.82, and the AUC 0.7902, 0.8120, and 0.9469, respectively. Conclusion The
combination of ultrasonography and mammography can increase the diagnostic accuracy for breast cancer within 2 cm.