Abstract: Objective To analyze the association between T393C single nucleotide polymorphism (SNP) of GNAS1 gene and
non-valvular atrial fibrillation (AF) in Chinese Han patients. Methods Ninety patients with non-valvular AF and 90 healthy
subjects were examined for T393C SNP of GNAS1 gene using polymerase chain reaction-restriction fragment length
polymorphism (PCR-RFLP). The allele genotypes and the distribution of allele frequencies were analyzed and compared
between the two groups. The relationship between allele frequency distribution characteristics and the heart rate variability
(HRV) were also studied for analysis of the association between T393C SNP of GNAS1 gene and the autonomic nervous
activation in non-valvular AF. Results The two groups showed a significant difference in the frequencies of genotypes of
T393C SNP of GNAS1 gene and allele frequencies (P<0.01). CC genotype and T393C allele frequency were significantly
increased in the case group. pNN50, LF, or LF/HF showed no significant difference between different genotypes (P<0.05).
Conclusion The T393C SNP of GNAS1 gene is closely associated with non-valvular AF in Chinese Han patients.