Abstract: Objective To inverstigate the clinicopathologic significance of pin1 and PR in patients with endometrial
adenocarcinoma. Methods The expression of pin1 and PR were investigated by immunohistochemistry in a total of 50
endometrial adenocarcinoma specimens. Results Pin1 was over expressed in 66%(33/50) of the cases. The expression rate
decreased gradually with tumor differentiation(P<0.05). In addition, pin1 expression was negatively correlated with lymph
node metastasis and invasive depth of myometrium. Moreover, pin1 was positively correlated with PR expression. Conclusion
Our results suggest that pin1 may play important roles in the tumorigenesis and migration of endometrial cancer. Pin1
expression may be considered as a prognostic marker as PR in patients with endometrial cancer.