Abstract: Objective To detect the expression of Nusap1 of surgical margins in hepatocellular carcinoma (HCC) and investigate
its association with early tumor recurrence. Methods The expression of Nusap1 in the surgical margins of HCC, which were
histopathologically negative for tumor cells, was examined using immunohistochemistry in 61 HCC cases. Results Fifteen of
21 (71.4%) cases with immunohistochemical positivity for Nusap1 expression in the surgical margins had early recurrence of
HCC, a rate significantly higher than that in patients with negative Nusap1 expression (12/40, 30%) (P<0.05). Conclusions
Nusap1 expression in the surgical margins of HCC is closely correlated to early postoperative recurrence and can serve as an
indicator for predicting early recurrence of HCC.