Abstract: Objective To explore the core mechanism of cell cycle compensation using a mathematical model. Methods A set of
ordinary differential equations were used to describe the interactions between the core cell cycle molecules. Continuous and
cyclic changes of the concentrations of these molecules were computed to capture the discrete events of molecular interactions.
Results The calculated molecule concentrations and captured signaling events agreed with the experimental results.
Conclusion E2F transcription factor 1 is the pivotal element linking the positive and negative feedbacks and regulating G1/S
and G2/M phase compensation.