Abstract: Objective To assess the feasibility and accuracy of CT coronary angiography (CTCA) combined with CT first-pass
myocardial perfusion imaging (CT first-pass MPI) at rest for diagnosis of obstructive coronary artery disease (CAD). Methods
Fifty-five patients, suspected or diagnosed as CAD, were performed with CTCA and CAG within 2 weeks. CT first-pass MPI
detected myocardial ischemia through analyzing the raw date of CTCA. Results Comparison with the results of CAG, the
sensibility, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of CT first-pass MPI at
rest for detecting obstructive CAD were 84.6%, 68.8%, 86.8%, 64.7% and 80.0%, respectively; and 92.3%, 93.8%, 97.3%, 83.3%,
92.7% for CTCA combined with CT first-pass MPI, respectively. Conclusions CTCA combined with CT first-pass MPI at rest
could detect obstructive CAD feasibly and accurately.