Abstract: ObjectiveTo evaluate the protective effect of amlodipine against contrast agent-induced renal injury in elderly
patients with coronary heart disease.MethodsA total of189 elderly patients (>60 years) with coronary heart disease
undergoing coronary artery angiography were randomly assigned into amlodipine group andcontrol group to receive
amlodipine or placebo, respectively, before and after administration of the contrast agent. At24h,48h and5days after
contrast agent administration, the parameters of renal function were measured including serum cystatin C, urea nitrogen,
creatinine, creatinine clearance rate, urineβ2-microglobulin, and urine N-acetyl-β-glucosaminidase. ResultsIn both groups,
the contrast agents obviously affected the renal functions of the patients (P<0.05). At 24h after contrast administration, the
levels of serum cystatin C, urine β2-microglobulin and urine NAG were significantly lower in amlodipine group than in the
control group, but the other functional parameters showed no significant difference. At48h after contrast administration, the
glomerular and tubular functional parameters were all superior in amlodipine group (P<0.05). At 5days, the two groups
showed significant differences in such glomerular and tubular functional parameters as urea nitrogen, creatinine, creatinine
clearance rate, urineβ2-microglobulin, and urine NAG (P<0.05), but not in serum cystatin C level. The incidence of contrast
agent-induced nephropathy was significantly lower in amlodipine group than in the control group (5/95vs10/94, P<0.05).
ConclusionsAmlodipine offers protection against radiographic contrast agent-induced renal injury in elderly patients with
coronary heart disease.