Abstract: Objective To explore the effects of ureteral stent placement on ureteral peristalsis and the time course of renal pelvic pressure changes.Methods Forty rabbits were randomized equally into 8 groups, including a control group without placement of ureteral stents. The other 7 groups received ureteral stent placement, which were retained for 0, 1, 2, 3, 4, 7, and 12 weeks respectively. When the rabbits were bred for the specified time periods, ureteral peristalsis was observed and renal pelvic pressure measured.Results The renal pelvic pressure was initially increased after the stent placement, but then followed by gradual deceases. Ureteral peristalsis was not observed after the stent placement.Conclusion Ureteral stent is a factor for causing obstruction in normal ureter.