Abstract: Objective To study the effects of hemoperfusion and/or hemodialysis on plasma levels of intact parathyroid hormone (iPTH) in patients with chronic renal failure (CRF). Methods A total of 40 uremic patients were randomly divided into two groups to receive hemoperfusion in combination with hemodialysis (HP+HD) or exclusive hemodialysis (HD), respectively. Plasma iPTH concentration was measured by means of radio immunoassay. Results After the blood purification procedures, the patients’ plasma iPTH levels were reduced from 1 508.70±1 268.89 to 1 049.04±992.91 μg/ml (P<0.001) in HD group and from 1 600.70±1 151.15 to 745.47±785.02 μg/ml (P<0.001) in HP+HD group. Conclusion Blood purification with hemoperfusion plus hemodialysis may decrease plasma iPTH levels more efficiently than hemodialysis performed alone.