Association of the expressions of platelet-derived growth factor receptor and c-Fos with the biological characteristics of bladder cancer

Abstract

Abstract: Objective To elucidate the relation of platelet-derived growth factor receptor (PDGFR) and c-Fos protein expressions with human bladder transitional epithelial cell carcinoma (BTCC). Methods The expressions of PDGFR and c-Fos were investigated in 11 normal bladder tissue samples, 14 adjacent non-carcinoma tissues and 43 BTCC tissues by means of SP immunohistochemical technique. Results The c-Fos expression was found in the cell nuclei and cytoplasm, and PDGFR in the nuclear membrane, cytoplasm, and cellular membrane. PDGFR and c-Fos were detected in 81.40% and 48.83% of the BTCC tissues respectively, at the rates both significantly higher than those in normal and adjacent non-carcinoma tissues (P<0.05). Correlation between the expression of c-Fos and the tumor grading was noted (P<0.05). The expressions of PDGFR and c-Fos in tumor blood vessels were significantly higher than those in normal vessels. Conclusions The expressions of PDGFR and c-Fos might be involved in the development of BTCC, possibly related to the angiogenesis of the tumors. c-Fos expression can indicated the cell proliferative status of the BTCC.

CLC Number:

R737.14

YAO Hua-qiang¹, PENG Ying², ZHONG Zhi-zhen¹, HE Hui-xu³, LI Zhong-hua¹. Association of the expressions of platelet-derived growth factor receptor and c-Fos with the biological characteristics of bladder cancer[J]. Journal of Southern Medical University, 2004, 24(02): 177-179,183.

References

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