Journal of Southern Medical University ›› 2004, Vol. 24 ›› Issue (02): 161-163,167.

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Preparation and characterization of polybutylcyanoacrylate magnetic nanoparticles

REN Fei1, CHEN Jian-hai1, JIANG Yao-dong2, CHEN Zhi-liang1   

  1. 1. 第一军医大学南方医院药学部, 广东, 广州, 510515;
    2. 第一军医大学南方医院泌尿外科, 广东, 广州, 510515
  • Online:2004-02-20 Published:2004-02-20

Abstract: Objective To Prepare and characterize polybutylcyanoacrylate (PBCA) magnetic nanoparticles.Methods The suspension of PBCA magnetic nanoparticles was prepared by emulsion polymerization method. The particle size, size distri-bution, polydispersity and other parameters were determined by photon correlation spectroscopy and transmission electron microscopy, and the iron content in the nanoparticles by ultraviolet spectroscopy. Results The data of the particle size and size distribution of aqueous decanoic acid stabilized Fe3O4 magnetic fluids were acquired, and the influences of concentrations of butylcyanoacrylate (BCA) and Dextran-70 on the particle size and size distribution of PBCA magnetic nanoparticles were characterized. Conclusion We have for the first time successfully prepared stable suspension of PBCA magnetic nanoparti-cles by emulsion polymerization method at pH 6.3-6.4 in aqueous medium.

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