Gln192Arg polymorphism of the paraoxonase-1gene is not associated with Alzheimer’s disease in Chinese

Journal of Southern Medical University ›› 2004, Vol. 24 ›› Issue (04): 371-374.

Gln192Arg polymorphism of the paraoxonase-1gene is not associated with Alzheimer’s disease in Chinese

SHI Jia-jun^1,2, ZHANG Si-zhong¹, MA Cui², TANG Mou-ni², LIU Xie-he³, WANG Ying-cheng³, HAN Hai-ying², GUO Yang-bo², FENG Rong-mei², MIAO Guo-dong²

1. 四川大学华西医院医学遗传室, 教育部人类疾病生物治疗重点实验室人类疾病基因组学研究室, 四川, 成都, 610041;
2. 广州市精神病医院, 广东, 广州, 510370;
3. 四川大学华西医院心理卫生中心, 四川, 成都, 610041

Online:2004-04-20 Published:2004-04-20

Abstract

Abstract: Objective To explore the relationship between paraoxonase-1 (PON1) gene Gln192Arg polymorphism and sporadic Alzheimer’s disease (AD) in Chinese. Methods A total of 165 AD patients and 174 age-matched control subjects were enrolled in this study for examination of PON1 Gln192Arg and apolipoprotein E gene polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The distribution of PON1 allelic and genotypic frequencies did not significantly differ between AD patients and the control subjects, even after the stratification by ApoE-epsilon4 status. Conclusion Gln192Arg polymorphism of the PON1 gene is not associated with sporadic AD in Chinese.

CLC Number:

R596
Q78

SHI Jia-jun^1,2, ZHANG Si-zhong¹, MA Cui², TANG Mou-ni², LIU Xie-he³, WANG Ying-cheng³, HAN Hai-ying², GUO Yang-bo², FENG Rong-mei², MIAO Guo-dong². Gln192Arg polymorphism of the paraoxonase-1gene is not associated with Alzheimer’s disease in Chinese[J]. Journal of Southern Medical University, 2004, 24(04): 371-374.

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