Mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy

Abstract

Abstract: Objective To observe the effects of mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy. Methods A total of 102 cases of tubal ectopic pregnancy diagnosed at early stage were enrolled to receive oral mefepristone at the dose of 75 mg twice daily for 3 d and intramuscular injection with calcium leucovorin at 0.1 mg/kg 24 h after a single dose of methotrexate injection (1 mg/kg· b.w.). In the control group consisting of 86 similar cases, intramuscular injection with calcium leucovorin at 0.1 mg/kg was given 24 h after a single dose of methotrexate (1 mg/kg·b.w.). Results Ninety-four of the 102 cases (92.20%) receiving oral mifepristone combined with calcium leucovorin and methotrexate were cured, a curative rate significantly higher than that in the control group, where 70 cases (81.4%) were cured (P<0.05). Conclusion Mefepristone combined with methotrexate is safe and effective in the treatment of tubal ectopic pregnancy, without obvious side effects.

CLC Number:

R714.22

LI Zhuo-hua¹, QUAN Song². Mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy[J]. Journal of Southern Medical University, 2004, 24(07): 829-831.

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