Prognostic value of changes of peripheral blood T cell subsets after thermoradiotherapy for nasopharyngeal carcinoma

Abstract

Abstract: Objective To assess the prognostic value of changes of peripheral blood T cell subsets after thermoradiotherapy for nasopharyngeal carcinoma (NPC). Methods Peripheral blood T cell subsets in 20 normal subjects (control group), 30 NPC patients undergoing thermoradiotherapy, and 20 NPC patients undergoing radiotherapy were detected by flow cytometry. Results The percentages of CD3⁺CD4⁺ and CD8⁺CD28⁺ cells were decreased and the percentages of CD3⁺CD8⁺ and CD8⁺CD28^- cells increased as compared with the measurements in normal persons. One month after thermoradiotherapy, the percentages of CD3⁺CD4⁺ and CD8⁺CD28⁺ cells further decreased and the percentages of CD3⁺CD8⁺ and CD8⁺CD28^- cells further increased, which continued to worsen 3 months after the treatment and appeared to be related to the survival of the patients. Conclusion T cell subsets of NPC patients are abnormal and their immune functions depressed in NPC patients within a long period after thermoradio-therapy. CD8⁺CD28⁺ and CD8⁺CD28^- T cell subsets can be significant for prognostic assessment in these patients after ther-moradiotherapy.

CLC Number:

R453
R446.6

QIU Yu-rong, ZHENG Lei, YANG Chun-li, WEI Dong, SUN De-hua. Prognostic value of changes of peripheral blood T cell subsets after thermoradiotherapy for nasopharyngeal carcinoma[J]. Journal of Southern Medical University, 2004, 24(07): 818-820.

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