Preparation and characterization of podophyllotoxin-dipalmitoylphosphatidylcholine proliposome

Abstract

Abstract: Objective To prepare podophyllotoxin-dipalmitoylphosphatidylcholine (PPT-DPPC) proliposomes (PPT-DPPC-PL) for improvement of the stability of PPT-DPPC liposome. Methods Freeze-drying method was used to prepare PPT-DPPC-PL, and the particle morphology, size range, encapsulation efficiency and stability of PPT-DPPC liposome were investigated. Results After hydration of PPT-DPPC-PL, PPT-DPPC liposome appeared multivesicular under electron microscope and the particles were distributed homogenously with an average particle size of 1.45±0.38 μm. The encapsulation efficiency of PPT was 72.3%, and alter storage at 4 to 40℃ for Ⅰ to 6 months, the proliposome remained stable. Conclusion The prepared PPT-DPPC-PL particles by freeze-drying method are evenly distributed. The preparation method is relatively simple with higher embedding ratio and better stability.

CLC Number:

R979.19
R986

LIN Zhong-fang¹, ZENG Kang¹, ZHOU Zai-gao¹, LI Guo-feng², XIE Fang-ming¹, ZHU Xiao-liang¹, ZHANG San-quan¹. Preparation and characterization of podophyllotoxin-dipalmitoylphosphatidylcholine proliposome[J]. Journal of Southern Medical University, 2004, 24(07): 784-786,788.

References

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