Inhibition of river clam extract LX01 on human lung epithelial carcinoma cell line A549

Abstract

Abstract: Objective To explore the inhibition effect of river clam extract LX01 on human lung epithelial carcinoma (A549) in mice. Methods The inhibition ratio of LX01 on A549 was detected by MTT method. A549 was inoculated into BALB/c mice, and 2 days later, LX01 (50, 100, 200 mg/kg·d) were administrated for 15 days. Tumor weight, survival time and leukocyte count were measured. Results Tumor growth was markedly inhibited by LX01 in a dose-depenner. LX01 could significantly extend the survival time compared with the control group (P<0.01), but LX01 did not reduce leukocyte count of mice transplanted with A549. Conclusion LX01 could efficiently inhibit the growth of A549 transplanted into mice and maintain the normal immunological function.

CLC Number:

R730.53

WANG Shun-guan¹, LI Lin². Inhibition of river clam extract LX01 on human lung epithelial carcinoma cell line A549[J]. Journal of Southern Medical University, 2004, 24(08): 917-920.

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