Value of magnesium sulfate and/or valium in preventing local anesthetic toxicicity of sacral block

Abstract

Abstract: Objective To study the effects of magnesium sulfate and/or valium in preventing local anesthetic toxicicity induced by sacral block.Methods A total of 240 adult patients scheduled for sacral block were randomized equally into four groups matched for sex,age and body weight. Ten minutes before sacral block,the patients in group B received valium (0.1mg/kg),group C received magnesium sulfate (50mg/kg),group D received both valium (0.1mg/kg) and magnesium sulfate (50 mg/kg). The control (group A) received neither valium nor magnesium sulfate. Local anesthetic toxicity was observed and recorded in all the groups. Results Local anesthetic toxicity was significantly decreased in group B and group C compared with group A (P<0.05),and the toxicity was even more significantly decreased in group D(P<0.01vsgroup A).Conclusion Local anesthetic toxicity of sacral block can be significantly decreased by intravenous injection of valium or magnesium sulfate,and their combination produces stronger effects.

CLC Number:

YANG Tian-ming, FAN Xin-ming, FAN Xue-liang. Value of magnesium sulfate and/or valium in preventing local anesthetic toxicicity of sacral block[J]. Journal of Southern Medical University, 2004, 24(10): 1205-1206,1209.

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