Association of interleukin-1 gene polymorphism with gastric cancer in a high-risk area of China

Abstract

Abstract: Objective To study the difference in the frequencies of interleukin-1B (IL-1) +3954,-511,-31 and IL-1RN gene polymorphism between gastric cancer patients and normal subjects in Shaanxi Province,a high risk area of gastric cancer of China.Methods The genomic DNA was extracted from the peripheral blood of 169 normal subjects and 86 gastric cancer patients in Shaanxi Province. IL-1 polymorphisms were analyzed using PCR-restriction fragment length polymorphism (PCR- RFLP). Results T/T genotype frequencies of IL-1 in +3954,-511,-31 and IL-1RN loci were similar between gastric cancer patients and normal subjects (χ² = 0, 0.04,0.3 and 0,P>0.05,respectively).Conclusion IL-1 gene polymorphism may be not associated with the risk of gastric cancer in this high-risk area.

CLC Number:

R735.1

HU Sheng¹, SONG Qi-bin¹, YU Ding¹, KE Yu-hua¹, HU Pin-jing², ZENG Zhi-rong². Association of interleukin-1 gene polymorphism with gastric cancer in a high-risk area of China[J]. Journal of Southern Medical University, 2004, 24(10): 1171-1173.

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