Expressions of Fas/FasL and granzyme B in oral lichen planus and their significance

Abstract

Abstract: Objective To define the association of the expressions of Fas/FasL and granzyme B with cell apoptosis in oral lichen planus (OLP) and progression of the disease. Method Immunohistochemical method and TUNEL were employed to study the expressions of Fas, FasL and granzyme B and cell apoptosis in 50 OLP cases (including 20 cases of atrophic-erosive OLP and 30 nonerosive OLP cases) and 10 normal oral mucosa specimens. Results Compared with the control group, the OLP cases showed increased apoptotic index (AI, 95.32±28.99) in the epithelial layer and the decreased AI (35.12±9.89) in the lamina propria (P<0.05), with the apoptotic cells confined within the basal or suprabasal cell layer instead of the superficial cell layer in the control group. The positivity rates of FasL and granzyme B expression were both 68% in the lamina propria of the OLP cases, remarkably higher than those in the normal control group (P<0.05); significantly higher rates were noted in atrophic-erosive than in nonerosive OLP cases (P<0.05). Conclusions The AI significantly differs between the epithelial layer and lamina propria in OLP cases, for which the expressions of Fas, FasL and granzyme B might be held responsible. The over-expressions of FasL and granzyme B are closely related to the progression of OLP.

CLC Number:

Q255
R593

SHEN Li-Jia^1,3, RUAN Ping¹, XIE Fang-fang², ZHAO Tong³. Expressions of Fas/FasL and granzyme B in oral lichen planus and their significance[J]. Journal of Southern Medical University, 2004, 24(12): 1362-1366.

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