Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy

Abstract

Abstract: Objective To observe the changes in urine albumin (UALB), von Willebrand factor (vWF) and platelet-activating factor (PAF) in different courses of type 2 diabetes. Methods Levels of UALB, vWF and PAF were determined in 30 type 2 diabetic nephropathy patients(group A), type 2 diabetic patients without DNP(group B, n=30), patients with impaired glucose tolerance (group C, n=30), the first-degree relatives of type 2 diabetic patients with normal glucose tolerance(group D, n=30) and 30 normal glucose tolerance subjects without family history of type 2 diabetes(group E). Results UALB and PAF contents were significantly higher in group A than in the other groups (P<0.01), while between the latter 4 groups, the contents showed no significant differences (P>0.05). Serum vWF level was significantly higher in group A than those in the other groups (P<0.05). Conclusion Renal dysfunction and platelet activation are present in type 2 diabetes with microvascular complications, and the synchronized changes between renal dysfunction and platelet activation indicate the involvement of elevated PAF in vascular injury.

CLC Number:

R587.1

FANG Yong-hong, ZHANG Ji-Ping, ZHOU Shao-xiong, ZHENG Ju-fen, YU Yong-wei, YAN Shi-gang, FAN Wen-kui, CHENG Yue-song. Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy[J]. Journal of Southern Medical University, 2005, 25(06): 729-731.

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[2]	CHEN Shi-wei1,3, ZHANG Li-shi1, ZHANG Hong-min2, FENG Xiao-fan1 1Department of Nutrition and Food Hygiene, West China School of Public Health, 2Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China; 3Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450003, China. Effects of soy isoflavone on levels of low-grade inflammatory peptides in rats with insulin resistance [J]. Journal of Southern Medical University, 2006, 26(10): 1484-1486.
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