Expressions of nuclear factor-kappaB and intercellular adhesion molecule-1 in endometriosis

Abstract

Abstract: Objectives To investigate the association of nuclear factor-kappaB (NF-κB) and intercellular adhesion molecule-1 (ICAM-1) with endometriosis. Methods Immunohistochemistry was used to examine the NF-κB and VEGF protein expres-sion in 35 specimens of normal endometrium, 48 eutopic endometrium of endometriosis and 76 ectopic endometrium, and the results were analyzed statistically. Results The expressions of NF-κB and ICAM-1 were found mainly in the glandular epithelial cells of the three endometrium specimens, with the ectopic endometriotic tissues showing the highest and normal endometrium the lowest expressions (P<0.001). NF-κB and ICAM-1 expressions were positively correlated to normal, eutopic and ectopic endometrium (r=0.688, 0.773 and 0.777, respectively, P<0.01). Conclusion NF-κB and ICAM-1 may participate in the process of the pathogenesis in endometriosis.

CLC Number:

R711.71

WANG Fang, HE Yuan-li, PENG Dong-xian, LIU Mu-biao. Expressions of nuclear factor-kappaB and intercellular adhesion molecule-1 in endometriosis[J]. Journal of Southern Medical University, 2005, 25(06): 703-705.

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