Abstract: Objective To investigate the relation of liver mass to, liver hymodynamics and soluble intercellular adhesion molecule-1 in patients with liver cirrhosis. Methods The liver mass was measured by liver biopsy, hepatic hemodynamics by ultrasonography, and the contents of hyalurionic acid (HA), human procollagenⅢ (HPCⅢ ) and collagen type Ⅳ (C Ⅳ ) by radioimmunoassay in 100 patients with liver cirrhosis in compensation stage and 30 normal control subjects. Results Greater liver mass was accompanied by more severe liver fibrosis and reduced liver blood flow. The contents of HA, HPCⅢ and C Ⅳ were obvious higher in the patients than in the normal controls (P<0.05) and increased with the liver mass. The liver mass was positively related to serum liver fibrosis indices (r=0.5612, P<0.05). Conclusion Liver mass in patients with liver cirrhosis is related to hepatic hemodynamics, indices for liver fibrosis and liver pathology.