Abstract: Objective To evaluate the therapeutic effects of Guliu capsule (GLC) combined with ⁸⁹Sr in treating metastatic bone tumors. Methods On the basis of random sampling and grouping, 50 patients with metastatic bone tumors were selected to receive combined treatment with GLC and ⁸⁹Sr with another 50 patients recruited for ⁸⁹Sr treatment alone. The therapeutic effect of the therapies were evaluated according to the relief of ostalgia and quality-of life (QOF), local bone metabolism and hematopoietic function of the bone marrow. Results The efficacy rate of GLC+⁸⁹Sr and ⁸⁹Sr in relieving ostalgia was 94.0% and 76.0%, and the rate of QOF improvement and stabilization was 94.0% and 74.0%, respectively, both showing significant difference between the two groups (P<0.05). The effect of the two treatment protocols on local bone metabolism and their hemotoxicity were also significantly different (P<0.05, P<0.01, respectively). Conclusion Combined treatment with GLC and ⁸⁹Sr is effective for metastatic bone tumor and improves the patient’s QOF with enhanced ostalgia relief rate and decreased hemotoxicity.