Abstract: Objective To study the extraction process for reforming the traditional preparation process of Baohe Wan. Method Using the recovery rate of total flavanoids of Baohe Wan and pharmacodynamic effects as indices, different extraction processes were compared. Results Supercritical carbon dioxide fluid extraction combined with water extraction was optimal for the extraction, and the extract prepared by the new process was pharmacodynamically more potent than the original Baohe Wan, as demonstrated by the rate of carbon powder moving in the small intestine and stomach emptying rate in mice. Conclusion Supercritical carbon dioxide fluid extraction combined with water extraction is practical for optimizing the preparation of Baohe Wan.