Expressions of FHIT and cyclin D1/CDK4 in oral cancer and oral precancerous lesions

Abstract

Abstract: Objective To detect the expressions of fragile histidine triad (FHIT) and cyclin D1/CDK4 in oral squamous cell carcinoma (OSCC) and oral precancerous lesions and investigate the relationship between the expressions and the histopatho- logical changes. Methods Immunohistochemical staining by SP methods was utilized to detect the expression of FHIT and cyclin D1/CDK4 in 64 cases of OSCC,39 oral precancerous lesions and 12 normal oral mucosa specimens. Results The rate of the negative or low FHIT expression in OSCC was 17% (11/64),which was remarkably lower than that in normal oral membrane and oral precancerous lesions (P<0.01).Significantly higher levels of cyclin D1/CDK4 expressed in OSCC than in normal oral membrane and precancerous lesions (P<0.01).There was no significant correlation between FHIT and cyclin D1/CDK4,and positive correlation between cyclin D1 and CDK4 was observed. Conclusion FHIT,cyclin D1 and CDK4 may play a role in the pathogenesis of OSCC,and FHIT can down-regulate the expression of cyclin D1.

CLC Number:

R781

YIN Cao¹, SHEN Li-jia², XIE Si-ming², RUAN Ping², YAO Xi². Expressions of FHIT and cyclin D1/CDK4 in oral cancer and oral precancerous lesions[J]. Journal of Southern Medical University, 2005, 25(07): 812-814.

References

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